Immunogen Design for Induction of HIV Distal gp41 Broadly Neutralizing Antibodies
SHIV/HIV Env-Antibody Coevolution as a Guide to Iterative Vaccine Design
A major roadblock to rational HIV-1 vaccine design is the lack of an animal model where the induction of broadly neutralizing antibodies (bNAbs) can be achieved in a consistent and reproducible way such that the molecular events responsible for bNAb elicitation can be deciphered and used to inform and guide iterative HIV-1 vaccine design. Dr. George Shaw, from the University of Pennsylvania, will work in collaboration with DHVI Investigators, Drs. Garnett Kelsoe and Wilton Williams, to develop a new strategy to overcome this roadblock by using novel SHIVs as immunogens and novel B cell analytics to elucidate Env-Ab coevolutionary pathways, leading to innovative new strategies in B lineage based vaccine design.