Limiting Antigen (LAg) Avidity Incidence Assay

The EQAPOL Limiting Antigen (LAg) Avidity Incidence Assay EQA program is the result of a collaboration between EQAPOL, the Centers for Disease Control and Prevention (CDC), and Blood Systems Research Institute (BSRI). The program assesses the proficiency of NIAID/DAIDS-supported and other interested research laboratories at performing the LAg incidence assay. Proficiency is assessed with the goal of helping all participating laboratories to perform the assay. Participating laboratories are required to complete two External Proficiency (EP) rounds per year.

As part of the program, EQAPOL provides the sites with a panel of human plasma samples to perform in the Sedia and/or Maxim LAg assays. Initial rounds of testing are aimed to collecting enough data to be used in the creation of grading criteria for future send-outs as well as evaluating site performance. Statistical assessment, troubleshooting, final report and discussion of results occur between participating laboratories and EQAPOL/NIAID. For each EP, sites are provided with a detailed report. Participating laboratories are blinded with a unique EQAPOL site ID, and each laboratory is unblinded with respect to only their data sets.

Current EP Testing

EP6

  • August 2019: EP6 shipments begin

Completed EP Testing 

EP5

  • January 2019: EP5 shipments begin
  • April 2019: EP5 data collection closes
  • May 2019: EP5 reports released

EP4

  • August 2018: EP4 shipments begin 
  • December 2018: EP4 data collection closes 
  • January 2019: EP4 reports released

EP3

  • January 22, 2018: EP3 shipments begin
  • March 14, 2018: EP3 data collection closes
  • June 2018: EP3 reports released

EP2

  • January 2017: EP2 shipments begin
  • March 29, 2017: EP2 data collection closes
  • June 6, 2017: EP2 reports released

EP1

  • January 25, 2016: EP1 shipments begin
  • April 25, 2016: EP1  data collection closes
  • June 23, 2016: EP1 reports released

Once available, site reports for EQAPOL LAg can be accessed using the EQAPOL web-based application (https://eqapolapp.dhvi.duke.edu).

United States

Sedia Biosciences Corporation
4900 NE 122nd Avenue
Portland, Oregon 97230
United States
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Maxim Biomedical
855 North Wolfe Street
1500 East Gude Drive, #A
Rockville, Maryland 20850
United States
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Johns Hopkins University
855 North Wolfe Street
Rangos Bldg, Room 527
Baltimore, Maryland 21209
United States
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Centers for Disease Control and Prevention
1600 Clifton Road
Bldg 15/Room 2401
Atlanta, Georgia 30345
United States
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Vitalent Research Institute
270 Masonic Avenue
San Francisco, California 94127
United States
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Singapore

National Public Health Laboratory
16 Jalan Tan Tock Seng
Singapore 308442
Singapore
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Brazil

Brazil - UCS
Rua Francisco Getulio Vargas, 1130
Bloco S - Sala 315
Caxias do Sul, Rio Grande do Sul 95070-560
Brazil
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Oswaldo Cruz Institute, FIOCRUZ
Av. Brasil, 4365 - Manguinhos
Leonidas Deane Building, Room 415
Rio de Janeiro 21040-900
Brazil
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Kenya

KEMRI/CDC
P.O. Box 1578-40100
Kisumu, Western 40100
Kenya
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National HIV Reference Laboratory
P.O. Box 20750
Kenyatta National Hospital Grounds, Near Nascope
Nairobi Kenya
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Botswana

Botswana-Harvard AIDS Institute
Plot 1836 North Ring Road
Princess Marina Hospital
Gaborone, South East Botswana
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Zambia

Tropical Diseases Research Centre
P.O. Box 71769
Ndola Central Hospital, 7th Floor
Ndola Zambia
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United Kingdom

Public Health England
61 Colindale Avenue
London NW9 5HT
United Kingdom
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Thailand

National Institute of Health
88/7 Tiwanon Road, Maung
Department of Medical Sciences
Nonthaburi 11000
Thailand
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Bangkok Metropolitan Administration
Bangkok Thailand
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AFRIMS
315/6 Phayathai
Rajchatheevee
Bangkok 10400
Thailand
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South Africa

National Institute of Communicable Diseases
1 Modderfontein Road Sandringham
HIV Sero-Molecular Laboratory, AIDS Building, Block C, Lower Ground
Johannesburg 2131
South Africa
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Canada

National HIV/AIDS Laboratories
JC Wilt Infectious Disease Center
c/o National Microbiology Laboratory
Winnipeg R3E 3L5
Canada
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Spain

CEEISCAT
Hospital Germans Trias i Pujol
Servei de Microbiologia. Hospital Germans Trias i Pujol. Carretera del Canuet s/n
Badalona 08019
Spain
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