The Duke Center for HIV Structural Biology (DCHSB) provides new insights into dynamics of HIV-1 entry and fusion with the host membrane, the Env-initiated immune activation of B cell receptors, and the role of anti-Env antibodies in blocking viral rebound.

The DCHSB pursues structural studies that aim to:

  • Develop a complete, time resolved and atomically detailed mechanism of HIV-1 Env fusion
  • Define BCR complex structures with specificity of autologous (anAb) and broadly neutralizing antibodies (bnAb)
  • Achieve an atomic level understanding of antibody-mediated control of rebound from latent HIV-1 reservoirs

The ultimate goal of these studies is to advance structural biology techniques and knowledge of HIV-1 Env structure-derived disease mechanisms in HIV-1 infection and rebound. Additionally, through its Developmental Core, the DCHSB will provide resources and training opportunities for early career investigators and trainees who are pursuing careers in the field of HIV-1 structural biology.

The Duke Center for HIV Structural Biology (DCHSB) invites proposals for an HIV research funding opportunity (Collaborative Development Awards - CDA). Early-career HIV investigators and investigators new to HIV research from under-represented racial and ethnic groups are encouraged to apply.

The program is intended to broadly support HIV-related structural studies aligned with the goals of the Center.

Applications must be submitted electronically no later than September 12, 2022, 5:00 p.mEST

The award covers one year of funding up to $175,000 in total costs. Applications will be peer-reviewed by a panel convened by the Center’s investigators.  Proposals will be evaluated on scientific merit, rigor, quality of project, and impact on HIV structural science. Our intent is to complete reviews and start funding by December 1, 2022.

Additional details and application information can be found at the link below.