The Duke Center for HIV Structural Biology (DCHSB) provides new insights into dynamics of HIV-1 entry and fusion with the host membrane, the Env-initiated immune activation of B cell receptors, and the role of anti-Env antibodies in blocking viral rebound.
The DCHSB pursues structural studies that aim to:
- Develop a complete, time resolved and atomically detailed mechanism of HIV-1 Env fusion
- Define BCR complex structures bound to specific autologous and broadly neutralizing antibodies (anAb and bnAb)
- Achieve an atomic level understanding of antibody-mediated control of rebound from latent HIV-1 reservoirs
The ultimate goal of these studies is to advance structural biology techniques and knowledge of HIV-1 Env structure-derived disease mechanisms in HIV-1 infection and rebound. Additionally, through its Developmental Core, the DCHSB will provide resources and training opportunities for early career investigators and trainees who are pursuing careers in the field of HIV-1 structural biology.