Rory  Henderson
Assistant Professor in Medicine


Dr. Rory Henderson is an Assistant Professor in Medicine at Duke University, the Head of Molecular Modeling and Simulation in the Division of Structural Biology at the Duke Human Vaccine Insitute, and the Project 1 Lead for the Duke Center for HIV Structural Biology (DCHSB).

Dr. Henderson’s lab focuses on understanding how the dynamics of macromolecules of the immune system and its antigenic targets determine the immune response to infection and how these dynamics can be manipulated to guide the selection of a favorable antibody response. We utilize a diverse computational and experimental tool set to interrogate key pathogen and antibody dynamics and use rational design principles to design immunogens and probe putative functional mechanisms. 

With Dr. Henderson’s background in molecular modeling and simulation along with biochemical and cryo-electron microscopy (cryo-EM) techniques, he and his lab investigate these details at high spatial and temporal resolution. Together, these methods provide a promising approach toward accelerating the design and characterization of the next generation of vaccine immunogens.

After a Ph.D. in molecular physics, Ulrich Lorenz did a postdoc with Ahmed Zewail at Caltech, where he became interested in time-resolved and ultrafast electron microscopy. He is an Assistant Professor at EPFL in Lausanne, Switzerland, where his research is being supported by an ERC Starting Grant since 2016. His interests revolve around the development of new methods to image the dynamics of nanoscale systems at high spatial and temporal resolution. Recently, his group put forward a new approach to time-resolved cryo-electron microscopy that affords a time resolution of just a few microseconds, three orders of magnitude faster than previously possible. His group will apply this approach to observe the dynamics in HIV envelope fusion.

More information.

Assistant Professor in Medicine
2 Genome Ct, MSRB 2, Durham, NC 27710
Mailing address
2 Genome Ct, MSRB 2, Durham, NC 27710