November 16, 2018

Maternal and Infant Immunization to Eliminate Breast Milk Transmission of HIV-1 HIVRAD Scientific Advisory Board Meeting

Dr. Sallie Permar and UNC's Dr. Kristina De Paris lead discussions on future studies to advance pediatric vaccine development at the Maternal and Infant Immunization to Eliminate Breast Milk Transmission of HIV-1 HIVRAD Scientific Advisory Board Meeting at Duke.

Why is there a need for pediatric HIV-1 vaccines?

There are 180,000 new infant HIV-1 infections annually, despite wide maternal ART coverage due to late presentation/diagnosis and acute maternal infection. Half of the pediatric infections are caused by breastfeeding. 1/3 of new infections are in 15-27 year olds.  Together, the HIVRAD research team will determine the feasibility, safety, and effectiveness of combined maternal and infant HIV-1 immunization as an alternative strategy for prevention of breast milk transmission of HIV-1 in the nonhuman primate model, an important step to designing effective maternal/infant HIV-1 vaccines that may be necessary to achieve an HIV-1 free generation.