Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Duke University School of Medicine
Over the past eleven years, I have built an independent basic research and immune monitoring laboratory with continuous NIH and Bill & Melinda Gates Foundation funding and continue to develop productive collaboration within and outside Duke University Medical Center, allowing me to expand my focus of research. Overall, I have been interested in understanding the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates. Lately, I have also started investigating the influence of CD4+ T cell responses that may support the production of broadly neutralizing Ab following HIV-1 infection. In summary, the research in my laboratory revolves around three topics of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in T cellular subsets upon infection with HIV-1.