Zika virus is a mosquito-borne virus that causes a mild febrile illness in adults and has recently been associated with birth defects including microcephaly when infection occurs during pregnancy. The current Zika virus outbreak has spread to 37 countries and has been declared a global health emergency by the World Health Organization. In response to the current epidemic activity of Zika virus the Duke Regional Biocontainment Laboratory Virology Unit has procured numerous Zika virus isolates and is actively working with investigators across the Institute.   Areas of significant interest include: vaccine development, immune response mechanisms, immune surveillance, development of animal models and mechanisms of virus pathogenesis.