April 06, 2020

DHVI Faculty Appointments

The DHVI is pleased to announce the faculty appointments of Drs. Rory Henderson and Andrew Macintrye to Assistant Professor.

Rory Henderson grew up in Arkansas where he earned an undergraduate degree and a Ph.D. from the University of Arkansas in Fayetteville. His Ph.D. research focused on the structural dynamics of the chloroplast signal recognition particle that is responsible for delivering light harvesting proteins to the chloroplast thylakoid membranes under the direction of Professor T.K.S. Kumar and in close collaboration with the labs of Professor Colin Heyes and Distinguished Professor Ralph Henry. After graduating, he took a postdoctoral position in the labs of Professor Munir Alam and DHVI director Barton Haynes. Bringing his combined computational and experimental approach to bear on the structural dynamics of the HIV-1 Envelope (Env) protein and broadly neutralizing antibodies, Dr. Henderson demonstrated the importance of a key region of flexibility in HIV-1 targeting antibodies termed the Fab elbow and developed a novel set of soluble HIV-1 Env immunogens. His lab continues to interrogate the role conformational dynamics plays in antibody maturation from both the antibody and immunogen perspective. With a long term goal of designing immunogens capable of eliciting specific mutations in maturing broadly neutralizing antibodies, his work will focus on the physics underlying the process of forming a macromolecular interaction including an interrogation of the ephemeral, collision induced encounter state.

 

 

Andrew Macintyre grew up in Scotland, where he earned an undergraduate degree in biochemistry at the University of Glasgow and a Ph.D. from the University of Dundee. His Ph.D. research focused on kinase regulation of T cell metabolism, and after graduating he took a postdoctoral position at Duke with Dr. Jeffrey Rathmell, a pioneer in the field of immunometabolism. During his time in Dr. Rathmell’s group, Dr. Macintyre collaborated with Dr. Valerie Gerriets and other members of the laboratory to show that glucose metabolism and the glucose transporter Glut1 were essential for CD4 effector T cell function but unnecessary for regulatory T cells. This discovery was published in the journal Cell Metabolism and was featured on the journal cover using an illustration drawn by Dr. Gerriets’ sister. This paper and its contemporaries demonstrated that adaptive inflammatory responses can be skewed by manipulating cellular metabolism.

After stints teaching biochemistry at Barton College in North Carolina and managing national education and diversity projects for the American Society for Biochemistry and Molecular Biology in Washington D.C., Dr. Macintyre returned to Duke in 2016 to manage the Immunology Unit of the Duke Regional Biocontainment Laboratory. The Unit is a core service laboratory that assists investigators in the design and implementation of assays to quantify immune reconstitution or immune responses in vitro and in vivo. In his new role as Assistant Professor, Dr. Macintyre is continuing to run the Unit while building a portfolio of independent research centered around vaccine development for Sexually transmitted infections (STIs). Among his current funded projects, Dr. Macintyre is the PI of the host response monitoring core for the Gonorrhea Vaccine Cooperative Research Center and is collaborating with clinical researchers at the University of North Carolina, Chapel-Hill, to evaluate novel vaccine strategies for Neisseria gonorrhea. His long term career goals are to improve our understanding of the molecular mechanisms by which bacterial STIs avoid triggering a robust immune response, identify and test strategies to enhance the immunological memory response to STIs, and to develop a network of DHVI and external collaborators with whom he can translate his research into vaccines.

 

*Official promotion date January 1, 2020