January 25, 2019

DHVI Director of Structural Biology Awarded R01

Congratulations to Dr. Priyamvada Acharya, Director of Structural Biology, on receiving her R01, titled: Structures of initial CD4 engagement with pre-fusion, closed HIV-1 Envelope trimer and early CD4-induced conformational changes required for infection.

In this study, Dr. Acharya's team will combine cryo-EM, x-ray crystallography and molecular dynamics to define the early, and yet unknown, CD4-induced conformational changes related to the opening of Env protomers, and movements of the HIV-1 fusion peptide.

This proposal has a significant contribution from Dr. Rory Henderson, who is currently a T32 postdoctoral fellow at DHVI.