DHVI Presentations at AIDS Vaccine 2013

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Oral Presentations

Pathways of Affinity Maturation of HIV-1 Broadly Neutralizing Antibodies
Barton Haynes
Duke Human Vaccine Institute, Durham, NC, United States of America
Lipid Components in MPER-based Immunization Regimens are Critical for Inducing Broadly Neutralizing Antibody Responses in 2F5 and 4E10 Knockin Mice
Laurent Verkoczy
Duke Human Vaccine Institute, Durham, NC, United States of America
Antibody Repertoire Induced by the Multiclade (Env A,B,C) HIV-1 DNA Prime, rAd5 Boost VRC Vaccine
Wilton B Williams
Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America
(slides and audio mp3 not available)
Vaccine Induced Epitope Specific Antibodies to the SIV Envelope are Distinct from Those Induced to the HIV-1 Envelope
Xiaoying Shen
Duke University, Human Vaccine Institute, Durham, NC, United States of America
HIV-1 gp120 Vaccination Elicits a Robust and Durable Anti-V1/V2 IgG Response and yet no HIV-1 Env-specific IgA Response in HIV-exposed Infants
Genevieve G. Fouda
Duke University Medical Center, Durham, NC, United States of America
Vaccine-Induced Antibody Responses in HVTN 505, a Phase IIb HIV-1 Efficacy Trial
Georgia Tomaras
Duke University, Durham, NC, United States of America
(slides and audio mp3 not available)

 

Poster Presentations

Isolation of mAbs from sorted single B cells by RT/PCR for analysis of B cell responses to HIV-1 MPER epitope in vaccinated rhesus macaques
Ruijun Zhang, M.A. Moody, M. S. Alam, J-S Yu, S. Santra, G. H. Kelsoe, S.M. Sekaran, R. Bhaskarabhatla, M-Y Wang, T.C. Gurley, A.A. Allen, L.C. Armand, D.J. Marshall, J. F. Whitesides, L. Sutherland, R.M. Scearce, A. Foulger, J. Pritchett, A. Hogan, R. De, C. Stolarchuk, E. Solomom, E. Friberg, Y. Yang, F. Gao, J.E. Schmitz, T.B. Kepler, B.F. Haynes, and H-X Liao
Duke Human Vaccine Institute, Duke University School of Medicine, Beth Israel Deaconess Medical Center, Department of Microbiology, Boston University

A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys
Maria Blasi, Donatella Negri, Sampa Santra, Robert Parks, Xiaoying Shen, Georgia Tomaras, Sallie Permar, David Montefiori, Celia Labranche, Guido Ferrari, Munir Alam, Hua-Xin Liao, Anthony Moody, Barton Haynes, Mary Klotman, and Andrea Cara
Duke University, Beth Israel Deaconess Medical Center

Heterogeneity of anti-V2 ADCC Ab Responses and Implications for Vaccine Development
Justin Pollara, Mattia Bonsignori, M. Anthony Moody, S. Munir Alam, Kwan-Ki Hwang, Thaddeus Gurley, Daniel Kozink, Dawn Marshall, John Whitesides, Chun-Yen Tsao, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Georgia Tomaras, Jerome Kim, Nelson Michael, Hua-Xin Liao, Barton Haynes, Guido Ferrari, and The Center for HIV/AIDS Vaccine Immunology
Duke University, Mahidol University, Armed Forces Research Institute of Medical Sciences, Clinical Tropical Medicine, Mahidol University, Department of Disease Control Ministry of Public Health, US Military HIV Research Program

Isolation and Characterization of an Autoreactive CD4bs Broad Neutralizing Antibody from a Chronic HIV-1 Controller with Systemic Lupus Erythematosus
Mattia Bonsignori, Kevin Wiehe, Rebecca Lynch, Sebastian Grimm, Daniel Kozink, Kwan-Ki Hwang, Joshua Eudailey, Guang Yang, Margaret Ackerman, Garnett Kelsoe, Hua-Xin Liao, Michael Moody, Thomas Kepler, David Montefiori, John Mascola, and Barton Haynes
Duke Human Vaccine Institute, Duke University Medical Center, Vaccine Research Center, NIH, Dartmouth College, Boston University School of Medicine

Structural Analysis of the Unmutated Common Ancestor Antibodies of the HIV Envelope V2 Antibodies CH58 and CH59 Derived from RV144 Vaccinees
Nathan Nicely, Kevin Wiehe, Thomas Kepler, Frederick Jaeger, S Dennison, Hua-Xin Liao, S Alam, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttithum, Janarit Kaewkungwal, Nelson Michael, Jerome Kim, and Barton Haynes
Duke Human Vaccine Institute, Duke University School of Medicine, Boston University, Ministry of Public Health, Armed Forces Research Institute of Medical Sciences, Mahidol University, Military HIV Research Program (MHRP), Walter Reed Army Institute of Research

Phylogenetic conservation of a dominant antibody light chain HIV Env V2 binding motif in human and rhesus macaque antibodies
Kevin Wiehe, David Easterhoff, Kan Luo, Walton Williams, Nathan Vandergrift, Krissey Lloyd, Christina Stolarchuk, Robert Parks, Nathan Nicely, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Nelson Michael, Jerome Kim, Georgia Tomaras, Mattia Bonsignori, Anthony Moody, Hua-Xin Liao, and Barton Haynes
Duke Human Vaccine Institute, Duke University School of Medicine, Duke University School of Medicine, Mahidol University, Armed Forces Research Institute of Medical Sciences, Ministry of Public Health, US Military Research Program, Walter Reed Army Institute of Research

Distinct VH Gene Usage and HIV Envelope Specificity of Colostrum and Peripheral B Cell Monoclonal Antibodies of HIV-Infected, Lactating African Women
Caitlin Sacha, Nathan Vandergrift, Dawn Marshall, Thad Gurley, Lauren Stiegel, John Whitesides, James Friedman, Genevieve Fouda, Brooke Liebl, Erin McGuire, Andrew Foulger, Thomas Kepler, Hua-Xin Liao, Barton Haynes, M. Moody, and Sallie Permar
Duke Human Vaccine Institute, Duke University School of Medicine, Boston University School of Medicine

Intestinal Commensal Bacteria Shape the Pre-transmission Antibody Repertoire to HIV-1 Infection
Ashley Trama, Hua-Xin Liao, Frederick Jaeger, S. Alam, Kevin Wiehe, Thomas Jeffries Jr., Andrew Foulger, William Williams, Dawn Marshall, Christina Stolarchuk, Krissey Lloyd, Robert Parks, Kelly Soderberg, Thomas Kepler, Nathan Vandergrift, Katherine Jackson, Andrew Fire, John Whitesides, Georgia Tomaras, M. Moody, and Barton Haynes
Duke Human Vaccine Institute, Duke University School of Medicine, Boston University, Stanford University

Combined Mucosal and Systemic C.1086 Envelope Immunization of Lactating Monkeys Induces Potent IgA and Functional IgG Antibody Responses in Milk
Erika Kunz, Genevieve Fouda, Carrie Ho, Joshua Amos, Lisa Colvin, David Montefiori, Amanda Martelli, Ashley Allen, Lawrence Aramand, Dawn Marshall, Norman Letvin, Herman Staats, David Pickup, Susan Barnett, M Moody, Barton Haynes, and Hua-Xin Liao
Duke Human Vaccine Institute, Duke University School of Medicine, Beth Israel Deaconess Medical Center, Novartis Vaccines and Diagnostics, Inc.

High Affinity Recognition of Synthetic Glycopeptides by HIV-1 gp120 V1V2 Loop Broadly Neutralizing Antibodies and Their Unmutated Common Ancestors
Munir Alam, Moses Dennison, Baptiste Aussedat, Yusuf Vohra, Peter Park, Alberto Fernández-Tejada, Shelley Stewart, Frederick Jaeger, Kara Anasti, Julie Blinn, Thomas Kepler, Hua-Xin Liao, Joseph Sodrosk, Samuel Danishefsky, and Barton Haynes
Duke Human Vaccine Institute, Duke University School of Medicine, Sloan-Kettering Institute for Cancer Research, Boston University School of Medicine, Dana-Farber Cancer Institute

Multiple pathways of HIV-1 autologous neutralizing antibodies cooperate to drive CD4 binding site broadly neutralizing antibody responses
Feng Gao, Mattia Bonsignori, Hua-Xin Liao, Amit Kumar, Shi-Mao Xia, Fangping Cai, Xiaozhi Lu, Daniel Kozink, Peter Kwong, Tongqing Zhou, Rebecca Lynch, S Alam, Guido Ferrari, Garnett Kelsoe, Gnanakaran Sandrasegaram, George Shaw, Beatrice Hahn, Gift Kamanga, Myron Cohen, Peter Braber, Bette Korber, John Mascola, Thomas Kepler, and Barton Haynes
Duke Human Vaccine Institute, Duke University School of Medicine, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Theoretical Division, Los Alamos National Laboratory, Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Departments of Health Policy and Management, University of North Carolina at Chapel Hill, Departments of Medicine, Epidemiology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Department of Microbiology, Boston University

Human HIV-1 Vaccine Induced Antibody Durability and Env IgG3 Responses
Kelly Seaton, Nicole Yates, William Williams, Larry Liao, Allan deCamp, Youyi Fong, David Montefiori, Paul Spearman, Marnie Elizaga, Susan Barnett, Marguerite Koutsoukos, Patricia Bourguignon, GSK PROHIV-002 Protocol Team, HVTN 088 Protocol Team, RV144 Protocol Team, VAX003 Protocol Team, Julie McElrath, Nelson Michael, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Jerome Kim, Gerald Voss, Peter Gilbert, Barton Haynes, and Georgia Tomaras
Duke Human Vaccine Institute, Duke University School of Medicine, Statistical Center for HIV/AIDS Research & Prevention (SCHARP), Duke University, Emory University, Fred Hutchinson Cancer Research Center, Novartis, GlaxoSmithKline (GSK), HVTN, USMHRP, GSID, Mahidol University, CDC Department, Ministry of Public Health

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