Mary E. Klotman, MD


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Professor of Medicine
Professor of Pathology
Professor in Molecular Genetics and Microbiology
Chair, Department of Medicine
Department / Division:
Medicine / Medicine-Infectious Diseases
DUMC 3703
Durham, NC 27710
Office Telephone:
  • MD, Duke University School of Medicine
  • Internal Medicine, Duke University Medical Center
  • Infectious Diseases, Duke University Medical Center
Clinical Interests:
General infectious diseases, HIV, infections in immuno-compromised hosts
Research Interests:
An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)
Representative Publications:
  • Blasi, M; Balakumaran, B; Chen, P; Negri, DR; Cara, A; Chen, BK; Klotman, ME. Renal epithelial cells produce and spread HIV-1 via T-cell contact. AIDS. 2014;28:2345-2353.  Abstract
  • Michelini, Z; Negri, D; Biava, M; Baroncelli, S; Spada, M; Leone, P; Bona, R; Blasi, M; Nègre, D; Klotman, ME; Cara, A. Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice. Viral Immunology. 2014;27:512-520.  Abstract
  • Blasi, M; Negri, D; Santra, S; Parks, R; Shen, X; Tomaras, G; Permar, S; Montefiori, D; LaBranche, C; Ferrari, G; Alam, M; Liao, H; Moody, AM; Haynes, BF; Klotman, ME; Cara, A. A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys. AIDS Research and Human Retroviruses. A161-A161.  
  • Hutter, R; Huang, L; Speidl, WS; Giannarelli, C; Trubin, P; Bauriedel, G; Klotman, ME; Fuster, V; Badimon, JJ; Klotman, PE. Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. Circulation. 2013;128:2351-2363.  Abstract
  • Micsenyi, AM; Zony, C; Alvarez, RA; Durham, ND; Chen, BK; Klotman, ME. Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells. Journal of Infectious Diseases. 2013;208:1756-1767.  Abstract
  • Todd, RF; Salata, RA; Klotman, ME; Weisfeldt, ML; Katz, JT; Xian, SX; Hearn, DP; Lipner, RS. Career outcomes of the graduates of the American Board of Internal Medicine Research Pathway, 1995-2007. Academic Medicine. 2013;88:1747-1753.  Abstract
  • Blasi, M; Rossi, A; Michelini, Z; Leone, P; Perretta, G; Cimarelli, A; Klotman, ME; Negri, D; Cara, A. Simian immunodeficiency virus-Vpx as an adjuvant for integrase defective lentiviral vector-based vaccines. Retrovirology. 2012;9.  
  • Negri, DR; Rossi, A; Blasi, M; Michelini, Z; Leone, P; Chiantore, MV; Baroncelli, S; Perretta, G; Cimarelli, A; Klotman, ME; Cara, A. Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines. Retrovirology. 2012;9:69.  Abstract
  • Chen, P; Chen, BK; Mosoian, A; Hays, T; Ross, MJ; Klotman, PE; Klotman, ME. Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells. Journal of the American Society of Nephrology : JASN. 2011;22:496-507.  Abstract
  • Ding, J; Rapista, A; Teleshova, N; Lu, W; Klotman, ME; Chang, TL. Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides. Journal of Innate Immunity. 2011;3:208-212.  Abstract
  • Jao, J; Palmer, D; Leus, I; Tih, P; Baweja, M; Klotman, M; Sperling, R; Wyatt, C. Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon. Nephrology Dialysis Transplantation. 2011;26:3051-3053.  Abstract
  • Papeta, N; Kiryluk, K; Patel, A; Sterken, R; Kacak, N; Snyder, HJ; Imus, PH; Mhatre, AN; Lawani, AK; Julian, BA; Wyatt, RJ; Novak, J; Wyatt, CM; Ross, MJ; Winston, JA; Klotman, ME; Cohen, DJ; Appel, GB; D'Agati, VD; Klotman, PE; Gharavi, AG. APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. Journal of the American Society of Nephrology : JASN. 2011;22:1991-1996.  Abstract