Nathan A. Vandergrift, PhD


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Assistant Professor in Medicine
Department / Division:
Medicine / Medicine - DHVI Faculty
Msrb Ii, 106 Research Drive
Box_103020 Med Ctr
Durham, NC 27710
Office Telephone:
(919) 681-8621
  • PhD, University of North Carolina at Chapel Hill, 2004
Representative Publications:
  • Fouda, GG; Cunningham, CK; McFarland, EJ; Borkowsky, W; Muresan, P; Pollara, J; Song, LY; Liebl, BE; Whitaker, K; Shen, X; Vandergrift, NA; Overman, RG; Yates, NL; Moody, MA; Fry, C; Kim, JH; Michael, NL; Robb, M; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Rerks-Ngarm, S; Liao, HX; Haynes, BF; Montefiori, DC; Ferrari, G; Tomaras, GD; Permar, SR. Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses. Journal of Infectious Diseases. 2015;211:508-517.  Abstract
  • Liu, M; Yang, G; Wiehe, K; Nicely, NI; Vandergrift, NA; Rountree, W; Bonsignori, M; Alam, SM; Gao, J; Haynes, BF; Kelsoe, G. Polyreactivity and autoreactivity among HIV-1 antibodies. Journal of virology. 2015;89:784-798.  Abstract
  • Dennison, SM; Anasti, KM; Jaeger, FH; Stewart, SM; Pollara, J; Liu, P; Kunz, EL; Zhang, R; Vandergrift, N; Permar, S; Ferrari, G; Tomaras, GD; Bonsignori, M; Michael, NL; Kim, JH; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Liao, HX; Haynes, BF; Alam, SM. Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide. Journal of virology. 2014;88:9406-9417.  Abstract
  • Liu, P; Williams, LD; Shen, X; Bonsignori, M; Vandergrift, NA; Overman, RG; Moody, MA; Liao, HX; Stieh, DJ; McCotter, KL; French, AL; Hope, TJ; Shattock, R; Haynes, BF; Tomaras, GD. Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. Journal of virology. 2014;88:5165-5170.  Abstract
  • Moody, MA; Santra, S; Vandergrift, NA; Sutherland, LL; Gurley, TC; Drinker, MS; Allen, AA; Xia, SM; Meyerhoff, RR; Parks, R; Lloyd, KE; Easterhoff, D; Alam, SM; Liao, HX; Ward, BM; Ferrari, G; Montefiori, DC; Tomaras, GD; Seder, RA; Letvin, NL; Haynes, BF. Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques. Journal of virology. 2014;88:3329-3339.  Abstract
  • Payne, TL; Blackinton, J; Frisbee, A; Pickeral, J; Sawant, S; Vandergrift, NA; Freel, SA; Ferrari, G; Keene, JD; Tomaras, GD. Transcriptional and posttranscriptional regulation of cytokine gene expression in HIV-1 antigen-specific CD8+ T cells that mediate virus inhibition. Journal of virology. 2014;88:9514-9528.  Abstract
  • Rountree, W; Vandergrift, N; Bainbridge, J; Sanchez, AM; Denny, TN. Statistical methods for the assessment of EQAPOL proficiency testing: ELISpot, Luminex, and Flow Cytometry. Journal of Immunological Methods. 2014;409:72-81.  Abstract
  • Trama, AM; Moody, MA; Alam, SM; Jaeger, FH; Lockwood, B; Parks, R; Lloyd, KE; Stolarchuk, C; Scearce, R; Foulger, A; Marshall, DJ; Whitesides, JF; Jeffries, TL; Wiehe, K; Morris, L; Lambson, B; Soderberg, K; Hwang, KK; Tomaras, GD; Vandergrift, N; Jackson, KJ; Roskin, KM; Boyd, SD; Kepler, TB; Liao, HX; Haynes, BF. HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria. Cell Host & Microbe. 2014;16:215-226.  Abstract
  • Yates, NL; Liao, HX; Fong, Y; deCamp, A; Vandergrift, NA; Williams, WT; Alam, SM; Ferrari, G; Yang, ZY; Seaton, KE; Berman, PW; Alpert, MD; Evans, DT; O'Connell, RJ; Francis, D; Sinangil, F; Lee, C; Nitayaphan, S; Rerks-Ngarm, S; Kaewkungwal, J; Pitisuttithum, P; Tartaglia, J; Pinter, A; Zolla-Pazner, S; Gilbert, PB; Nabel, GJ; Michael, NL; Kim, JH; Montefiori, DC; Haynes, BF; Tomaras, GD. Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination. Science Translational Medicine. 2014;6:228ra39.  Abstract
  • Carias, AM; McCoombe, S; McRaven, M; Anderson, M; Galloway, N; Vandergrift, N; Fought, AJ; Lurain, J; Duplantis, M; Veazey, RS; Hope, TJ. Defining the interaction of HIV-1 with the mucosal barriers of the female reproductive tract. Journal of virology. 2013;87:11388-11400.  Abstract
  • Fouda, GG; Mahlokozera, T; Salazar-Gonzalez, JF; Salazar, MG; Learn, G; Kumar, SB; Dennison, SM; Russell, E; Rizzolo, K; Jaeger, F; Cai, F; Vandergrift, NA; Gao, F; Hahn, B; Shaw, GM; Ochsenbauer, C; Swanstrom, R; Meshnick, S; Mwapasa, V; Kalilani, L; Fiscus, S; Montefiori, D; Haynes, B; Kwiek, J; Alam, SM; Permar, SR. Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants. Retrovirology. 2013;10:3.  Abstract
  • Liao, HX; Tsao, CY; Alam, SM; Muldoon, M; Vandergrift, N; Ma, BJ; Lu, X; Sutherland, LL; Scearce, RM; Bowman, C; Parks, R; Chen, H; Blinn, JH; Lapedes, A; Watson, S; Xia, SM; Foulger, A; Hahn, BH; Shaw, GM; Swanstrom, R; Montefiori, DC; Gao, F; Haynes, BF; Korber, B. Antigenicity and immunogenicity of transmitted/founder, consensus, and chronic envelope glycoproteins of human immunodeficiency virus type 1. Journal of virology. 2013;87:4185-4201.  Abstract
  • Yates, NL; Stacey, AR; Nolen, TL; Vandergrift, NA; Moody, MA; Montefiori, DC; Weinhold, KJ; Blattner, WA; Borrow, P; Shattock, R; Cohen, MS; Haynes, BF; Tomaras, GD. HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. Mucosal immunology. 2013;6:692-703.  Abstract
  • Moody, MA; Yates, NL; Amos, JD; Drinker, MS; Eudailey, JA; Gurley, TC; Marshall, DJ; Whitesides, JF; Chen, X; Foulger, A; Yu, JS; Zhang, R; Meyerhoff, RR; Parks, R; Scull, JC; Wang, L; Vandergrift, NA; Pickeral, J; Pollara, J; Kelsoe, G; Alam, SM; Ferrari, G; Montefiori, DC; Voss, G; Liao, HX; Tomaras, GD; Haynes, BF. HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages. Journal of virology. 2012;86:7496-7507.  Abstract
  • Liao, HX; Chen, X; Munshaw, S; Zhang, R; Marshall, DJ; Vandergrift, N; Whitesides, JF; Lu, X; Yu, JS; Hwang, KK; Gao, F; Markowitz, M; Heath, SL; Bar, KJ; Goepfert, PA; Montefiori, DC; Shaw, GC; Alam, SM; Margolis, DM; Denny, TN; Boyd, SD; Marshal, E; Egholm, M; Simen, BB; Hanczaruk, B; Fire, AZ; Voss, G; Kelsoe, G; Tomaras, GD; Moody, MA; Kepler, TB; Haynes, BF. Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. The Journal of Experimental Medicine. 2011;208:2237-2249.  Abstract
  • Liu, J; Miller, MD; Danovich, RM; Vandergrift, N; Cai, F; Hicks, CB; Hazuda, DJ; Gao, F. Analysis of low-frequency mutations associated with drug resistance to raltegravir before antiretroviral treatment. Antimicrobial agents and chemotherapy. 2011;55:1114-1119.  Abstract
  • Liu, P; Overman, RG; Yates, NL; Alam, SM; Vandergrift, N; Chen, Y; Graw, F; Freel, SA; Kappes, JC; Ochsenbauer, C; Montefiori, DC; Gao, F; Perelson, AS; Cohen, MS; Haynes, BF; Tomaras, GD. Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infection. Journal of virology. 2011;85:11196-11207.  Abstract
  • Moody, MA; Zhang, R; Walter, EB; Woods, CW; Ginsburg, GS; McClain, MT; Denny, TN; Chen, X; Munshaw, S; Marshall, DJ; Whitesides, JF; Drinker, MS; Amos, JD; Gurley, TC; Eudailey, JA; Foulger, A; DeRosa, KR; Parks, R; Meyerhoff, RR; Yu, JS; Kozink, DM; Barefoot, BE; Ramsburg, EA; Khurana, S; Golding, H; Vandergrift, NA; Alam, SM; Tomaras, GD; Kepler, TB; Kelsoe, G; Liao, HX; Haynes, BF. H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination. PloS one. 2011;6:e25797.  Abstract
  • Yates, NL; Lucas, JT; Nolen, TL; Vandergrift, NA; Soderberg, KA; Seaton, KE; Denny, TN; Haynes, BF; Cohen, MS; Tomaras, GD. Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection. AIDS. 2011;25:2089-2097.  Abstract
  • Moody, MA; Amos, JD; Gurley, TC; Drinker, MS; Luney, KD; Marshall, DJ; Whitesides, JF; Chen, X; Zhang, R; Derosa, K; Guogas, L; Vandergrift, NA; Voss, G; Liao, H; Tomaras, GD; Haynes, BF. Isolation of Human Monoclonal Antibodies from HIV-Uninfected Subjects Immunized with gp120/NefTat/AS01B by Dual-Color Antigen-Specific B Cell Sorting. AIDS Research and Human Retroviruses. A15-A15.  
  • Bonsignori, M; Hwang, K; Vandergrift, N; Moody, MA; Haynes, BF. P04-01. Simultaneous enumeration of HIV-1 gp41 Env-specific IgG and IgM antibody-secreting cells with a multiplex B-cell fluorospot assay. Retrovirology. 2009;6:P29.  
  • Bonsignori, M; Moody, MA; Parks, RJ; Holl, TM; Kelsoe, G; Hicks, CB; Vandergrift, N; Tomaras, GD; Haynes, BF. HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after envelope gp120 protein vaccination or HIV-1 infection. Journal of immunology (Baltimore, Md. : 1950). 2009;183:2708-2717.  Abstract
  • Bonsignori, M; Moody, MA; Parks, RJ; Holl, TM; Kelsoe, G; Hicks, CB; Vandergrift, N; Tomaras, GD; Haynes, BF. P04-48. HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after gp120 protein vaccination or chronic HIV-1 infection. Retrovirology. 2009;6:P76.  
  • Levesque, MC; Moody, MA; Hwang, KK; Marshall, DJ; Whitesides, JF; Amos, JD; Gurley, TC; Allgood, S; Haynes, BB; Vandergrift, NA; Plonk, S; Parker, DC; Cohen, MS; Tomaras, GD; Goepfert, PA; Shaw, GM; Schmitz, JE; Eron, JJ; Shaheen, NJ; Hicks, CB; Liao, HX; Markowitz, M; Kelsoe, G; Margolis, DM; Haynes, BF. Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. PLoS medicine. 2009;6:e1000107.  Abstract
  • Wong, JY; Whitby, LB; Vandergrift, NA; Louzao, R; Denny, TN; Barnett, D. ESTABLISHING LINEARITY OF FLOW CYTOMETERS: A NOVEL APPROACH USING STABILIZED WHOLE BLOOD. Cytometry. 376-376.