Thomas Norton Denny, MPhil, MS

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Professor in Medicine
Department / Division:
Medicine / Medicine - DHVI Faculty
Address:
106 Research Drive
Msrb Ii Bldg. Room 4077
Durham, NC 27710
Office Telephone:
(919) 681-1023
Training:
  • MPhil, University of Glasgow (Scotland), 2010
  • MS, University of East London (London, Uk), 2001
Research Interests:
Thomas N. Denny, MSc, M.Phil, is the Chief Operating Officer of the Duke Human Vaccine Institute (DHVI) and the Center for HIV/AIDS Vaccine Immunology (CHAVI), and a Professor of Medicine in the Department of Medicine at Duke University Medical Center. He is also an Affiliate Member of the Duke Global Health Institute. He has recently been appointed to the Duke University Fuqua School of Business Health Sector Advisory Council. Previously, he was an Associate Professor of Pathology, Laboratory Medicine and Pediatrics, Associate Professor of Preventive Medicine and Community Health and Assistant Dean for Research in Health Policy at the New Jersey Medical School, Newark, New Jersey. He has served on numerous committees for the NIH over the last two decades and currently is the principal investigator of an NIH portfolio in excess of 56 million dollars. Mr. Denny was a 2002-2003 Robert Wood Johnson Foundation Health Policy Fellow at the Institute of Medicine of the National Academies (IOM). As a fellow, he served on the US Senate Health, Education, Labor and Pensions Committee with legislation/policy responsibilities in global AIDS, bioterrorism, clinical trials/human subject protection and vaccine related-issues.

As the Chief Operating Officer of the DHVI, Mr. Denny has administrative oversight of a research portfolio of more than 400 million dollars and has the finance, program management, regulatory/compliance, intellectual property, facilities management, biosafety, human resources and information technology offices as direct reports. He has extensive international experience and previously was a consultant to the U.S. Centers for Disease Control and Prevention (CDC) for the President’s Emergency Plan for AIDS Relief (PEPFAR) project to oversee the development of an HIV and Public Health Center of Excellence laboratory network in Guyana. In September 2004, the IOM appointed him as a consultant to their Board on Global Health Committee studying the options for overseas placement of U.S. health professionals and the development of an assessment plan for activities related to the 2003 PEPFAR legislative act. Previously, Mr. Denny helped establish a small laboratory in the Republic of Kalmykia (former Soviet Union) to improve the care of children with HIV/AIDS. He is also a Board Member of the Children of Chernobyl Relief Fund Foundation. In 2005, Mr. Denny was named a consulting medical/scientific officer to the WHO Global AIDS Program in Geneva. He has also served as program reviewers for the governments of the Netherlands and South Africa as well as an advisor to several U.S. biotech companies. He currently serves as an advisor to Advanced Liquid Logics, Inc., which is headquartered in Durham, North Carolina.

Mr. Denny has authored and co-authored more than 95 peer-reviewed papers and serves on the editorial board of Communications in Cytometry and Journal of Clinical Virology. He holds an M.Sc in Molecular and Biomedical Immunology from the University of East London and a degree in Medical Law (M.Phil) from the Institute of Law and Ethics in Medicine, School of Law, University of Glasgow. In 1991, he completed a course of study in Strategic Management at The Wharton School, University of Pennsylvania. In 1993, he completed the Program for Advanced Training in Biomedical Research Management at Harvard School of Public Health. In December 2005, he was inducted as a Fellow into the College of Physicians of Philadelphia, the oldest medical society in the US.

While living in New Jersey, Mr. Denny was active in his community gaining additional experience from two publicly elected positions. In 1994, he was elected to the Cranford Board of Education, a K-12 district of more than 3,000 students and a budget exceeding thirty-million dollars. He served in various capacities before being elected vice-president of the Board in 1995. In 1996, Mr. Denny was elected to his first term on th
Representative Publications:
  • Bainbridge, J; Wilkening, CL; Rountree, W; Louzao, R; Wong, J; Perza, N; Garcia, A; Denny, TN. The Immunology Quality Assessment Proficiency Testing Program for CD3(+)4(+) and CD3(+)8(+) Lymphocyte Subsets: A ten year review via longitudinal mixed effects modeling. Journal of Immunological Methods. 2014;  Abstract
  • Garcia, A; Keinonen, S; Sanchez, AM; Ferrari, G; Denny, TN; Moody, MA. Leukopak PBMC sample processing for preparing quality control material to support proficiency testing programs. Journal of Immunological Methods. 2014;409:99-106.  Abstract
  • Kepler, TB; Munshaw, S; Wiehe, K; Zhang, R; Yu, JS; Woods, CW; Denny, TN; Tomaras, GD; Alam, SM; Moody, MA; Kelsoe, G; Liao, HX; Haynes, BF. Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation. Frontiers in Immunology. 2014;5:170.  Abstract
  • Lynch, HE; Sanchez, AM; D'Souza, MP; Rountree, W; Denny, TN; Kalos, M; Sempowski, GD. Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays. Journal of Immunological Methods. 2014;  Abstract
  • Meyer, SA; Westreich, DJ; Patel, E; Ehlinger, EP; Kalilani, L; Lovingood, RV; Denny, TN; Swamy, GK; Permar, SR. Postnatal cytomegalovirus exposure in infants of antiretroviral-treated and untreated HIV-infected mothers. Infectious Diseases in Obstetrics and Gynecology. 2014;2014:989721.  Abstract
  • Richards, AJ; Staats, J; Enzor, J; McKinnon, K; Frelinger, J; Denny, TN; Weinhold, KJ; Chan, C. Setting objective thresholds for rare event detection in flow cytometry. Journal of Immunological Methods. 2014;409:54-61.  Abstract
  • Roederer, M; Keele, BF; Schmidt, SD; Mason, RD; Welles, HC; Fischer, W; Labranche, C; Foulds, KE; Louder, MK; Yang, Z-Y; Todd, J-PM; Buzby, AP; Mach, LV; Shen, L; Seaton, KE; Ward, BM; Bailer, RT; Gottardo, R; Gu, W; Ferrari, G; Alam, SM; Denny, TN; Montefiori, DC; Tomaras, GD; Korber, BT; Nason, MC; Seder, RA; Koup, RA; Letvin, NL; Rao, SS; Nabel, GJ; Mascola, JR. Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature. 2014;505:502-508.  
  • Roederer, M; Keele, BF; Schmidt, SD; Mason, RD; Welles, HC; Fischer, W; Labranche, C; Foulds, KE; Louder, MK; Yang, ZY; Todd, JP; Buzby, AP; Mach, LV; Shen, L; Seaton, KE; Ward, BM; Bailer, RT; Gottardo, R; Gu, W; Ferrari, G; Alam, SM; Denny, TN; Montefiori, DC; Tomaras, GD; Korber, BT; Nason, MC; Seder, RA; Koup, RA; Letvin, NL; Rao, SS; Nabel, GJ; Mascola, JR. Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature. 2014;505:502-508.  Abstract
  • Rountree, W; Vandergrift, N; Bainbridge, J; Sanchez, AM; Denny, TN. Statistical methods for the assessment of EQAPOL proficiency testing: ELISpot, Luminex, and Flow Cytometry. Journal of Immunological Methods. 2014;  Abstract
  • Sambor, A; Garcia, A; Berrong, M; Pickeral, J; Brown, S; Rountree, W; Sanchez, A; Pollara, J; Frahm, N; Keinonen, S; Kijak, GH; Roederer, M; Levine, G; D'Souza, MP; Jaimes, M; Koup, R; Denny, T; Cox, J; Ferrari, G. Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials. Journal of Immunological Methods. 2014;  Abstract
  • Sanchez, AM; Demarco, CT; Hora, B; Keinonen, S; Chen, Y; Brinkley, C; Stone, M; Tobler, L; Keating, S; Schito, M; Busch, MP; Gao, F; Denny, TN. Development of a Contemporary Globally Diverse HIV Viral Panel by the EQAPOL Program. Journal of Immunological Methods. 2014;  Abstract
  • Sanchez, AM; Denny, TN; O'Gorman, M. Introduction to a Special Issue of the Journal of Immunological Methods: Building Global Resource Programs to Support HIV/AIDS Clinical Trial Studies. Journal of Immunological Methods. 2014;409:1-5.  Abstract
  • Sanchez, AM; Rountree, W; Berrong, M; Garcia, A; Schuetz, A; Cox, J; Frahm, N; Manak, M; Sarzotti-Kelsoe, M; D'Souza, MP; Denny, T; Ferrari, G. The External Quality Assurance Oversight Laboratory (EQAPOL) Proficiency Program for IFN-gamma Enzyme-Linked ImmunoSpot (IFN-¿ ELISpot) assay. Journal of Immunological Methods. 2014;  Abstract
  • Sarzotti-Kelsoe, M; Daniell, X; Todd, CA; Bilska, M; Martelli, A; LaBranche, C; Perez, LG; Ochsenbauer, C; Kappes, JC; Rountree, W; Denny, TN; Montefiori, DC. Optimization and validation of a neutralizing antibody assay for HIV-1 in A3R5 cells. Journal of Immunological Methods. 2014;409:147-160.  Abstract
  • Sarzotti-Kelsoe, M; Needham, LK; Rountree, W; Bainbridge, J; Gray, CM; Fiscus, SA; Ferrari, G; Stevens, WS; Stager, SL; Binz, W; Louzao, R; Long, KO; Mokgotho, P; Moodley, N; Mackay, M; Kerkau, M; McMillion, T; Kirchherr, J; Soderberg, KA; Haynes, BF; Denny, TN. The Center for HIV/AIDS Vaccine Immunology (CHAVI) multi-site quality assurance program for cryopreserved Human Peripheral Blood Mononuclear Cells. Journal of Immunological Methods. 2014;409:21-30.  Abstract
  • Smit, PW; Sollis, KA; Fiscus, S; Ford, N; Vitoria, M; Essajee, S; Barnett, D; Cheng, B; Crowe, SM; Denny, T; Landay, A; Stevens, W; Habiyambere, V; Perriens, JH; Peeling, RW. Systematic review of the use of dried blood spots for monitoring HIV viral load and for early infant diagnosis. PLoS One. 2014;9:e86461.  Abstract
  • Sollis, KA; Smit, PW; Fiscus, S; Ford, N; Vitoria, M; Essajee, S; Barnett, D; Cheng, B; Crowe, SM; Denny, T; Landay, A; Stevens, W; Habiyambere, V; Perrins, J; Peeling, RW. Systematic review of the performance of HIV viral load technologies on plasma samples. PLoS One. 2014;9:e85869.  Abstract
  • Staats, JS; Enzor, JH; Sanchez, AM; Rountree, W; Chan, C; Jaimes, M; Chan, RC; Gaur, A; Denny, TN; Weinhold, KJ. Toward development of a comprehensive external quality assurance program for polyfunctional intracellular cytokine staining assays. Journal of Immunological Methods. 2014;  Abstract
  • Todd, CA; Sanchez, AM; Garcia, A; Denny, TN; Sarzotti-Kelsoe, M. Implementation of Good Clinical Laboratory Practice (GCLP) guidelines within the External Quality Assurance Program Oversight Laboratory (EQAPOL). Journal of Immunological Methods. 2014;409C:91-98.  Abstract
  • Amos, JD; Wilks, AB; Fouda, GG; Smith, SD; Colvin, L; Mahlokozera, T; Ho, C; Beck, K; Overman, RG; DeMarco, CT; Hodge, TL; LaBranche, CC; Montefiori, DC; Denny, TN; Liao, HX; Tomaras, GD; Moody, MA; Permar, SR. Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys. Journal of Virology. 2013;87:11121-11134.  Abstract
  • Apps, R; Qi, Y; Carlson, JM; Chen, H; Gao, X; Thomas, R; Yuki, Y; Del Prete, GQ; Goulder, P; Brumme, ZL; Brumme, CJ; John, M; Mallal, S; Nelson, G; Bosch, R; Heckerman, D; Stein, JL; Soderberg, KA; Moody, MA; Denny, TN; Zeng, X; Fang, J; Moffett, A; Lifson, JD; Goedert, JJ; Buchbinder, S; Kirk, GD; Fellay, J; McLaren, P; Deeks, SG; Pereyra, F; Walker, B; Michael, NL; Weintrob, A; Wolinsky, S; Liao, W; Carrington, M. Influence of HLA-C Expression Level on HIV Control. Science. 2013;340:87-91.  Abstract
  • Ho, C; Wu, S; Amos, JD; Colvin, L; Smith, SD; Wilks, AB; Demarco, CT; Brinkley, C; Denny, TN; Schmitz, JE; Rodrigo, AG; Permar, SR. Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys. Journal of Virology. 2013;87:11292-11299.  Abstract
  • Liu, P; Yates, NL; Shen, X; Bonsignori, M; Moody, MA; Liao, HX; Fong, Y; Alam, SM; Overman, RG; Denny, T; Ferrari, G; Ochsenbauer, C; Kappes, JC; Polonis, VR; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Rerks-Ngarm, S; Montefiori, DC; Gilbert, P; Michael, NL; Kim, JH; Haynes, BF; Tomaras, GD. Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees. Journal of Virology. 2013;87:7828-7836.  Abstract
  • Marti, GE; Mandy, F; Denny, T; Preffer, FI. Concerning the article by de Carvalho Bittencourt et al.: Value of HIV patients with regular follow-up as in-house internal controls of flow cytometry measurement of lymphocyte subsets. Cytometry Part B: Clinical Cytometry. 2013;84:327-328.  
  • Parrish, NF; Gao, F; Li, H; Giorgi, EE; Barbian, HJ; Parrish, EH; Zajic, L; Iyer, SS; Decker, JM; Kumar, A; Hora, B; Berg, A; Cai, F; Hopper, J; Denny, TN; Ding, H; Ochsenbauer, C; Kappes, JC; Galimidi, RP; Jr, WAP; Bjorkman, PJ; Wilen, CB; Doms, RW; O'Brien, M; Bhardwaj, N; Borrow, P; Haynes, BF; Muldoon, M; Theiler, JP; Korber, B; Shaw, GM; Hahn, BH. Phenotypic properties of transmitted founder HIV-1. Proceedings of the National Academy of Sciences of USA. 2013;110:6626-6633.  Abstract
  • Barnett, D; Whitby, L; Wong, J; Louzao, R; Reilly, JT; Denny, TN. VERITAS?: A time for VERIQAS¿ and a new approach to training, education, and the quality assessment of CD4+ T lymphocyte counting (I). Cytometry Part B: Clinical Cytometry. 2012;82:93-100.  Abstract
  • Freel, SA; Picking, RA; Ferrari, G; Ding, H; Ochsenbauer, C; Kappes, JC; Kirchherr, JL; Soderberg, KA; Weinhold, KJ; Cunningham, CK; Denny, TN; Crump, JA; Cohen, MS; McMichael, AJ; Haynes, BF; Tomaras, GD. Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replication. Journal of Virology. 2012;86:6835-6846.  Abstract
  • Li, H; Stoddard, MB; Wang, S; Blair, LM; Giorgi, EE; Parrish, EH; Learn, GH; Hraber, P; Goepfert, PA; Saag, MS; Denny, TN; Haynes, BF; Hahn, BH; Ribeiro, RM; Perelson, AS; Korber, BT; Bhattacharya, T; Shaw, GM. Elucidation of hepatitis C virus transmission and early diversification by single genome sequencing. PLoS Pathogens. 2012;8:e1002880.  Abstract
  • Sarzotti-Kelsoe, M; Daniell, X; Todd, CA; Bilska, M; LaBranche, C; Perez, LG; Ochsenbauer, C; Kappes, J; Rountree, W; Ozaki, DA; Kim, JH; McLinden, R; Denny, T; Montefiori, DC. Optimization and validation of the HIV-1 neutralizing antibody assay in A3R5 cells. Retrovirology. 2012;9:P69-P69.  
  • Yang, H; Wu, H; Hancock, G; Clutton, G; Sande, N; Xu, X; Yan, H-P; Huang, X; Angus, B; Kuldanek, K; Fidler, S; Denny, T; Birks, J; McMichael, A; Dorrell, L. The antiviral inhibitory capacity of CD8+T cells predicts the rate of CD4+cell decline in HIV-1 infection. HIV Medicine. 2012;13:6-6.  
  • Yang, H; Wu, H; Hancock, G; Clutton, G; Sande, N; Xu, X; Yan, H; Huang, X; Angus, B; Kuldanek, K; Fidler, S; Denny, TN; Birks, J; McMichael, A; Dorrell, L. Antiviral inhibitory capacity of CD8+ T cells predicts the rate of CD4+ T-cell decline in HIV-1 infection. Journal of Infectious Diseases. 2012;206:552-561.  Abstract
  • Curtis, MG; Walker, B; Denny, TN. Flow cytometric methods for prenatal and neonatal diagnosis. Journal of Immunological Methods. 2011;363:198-209.  Abstract
  • Fouda, GG; Yates, NL; Pollara, J; Shen, X; Overman, GR; Mahlokozera, T; Wilks, AB; Kang, HH; Salazar-Gonzalez, JF; Salazar, MG; Kalilani, L; Meshnick, SR; Hahn, BH; Shaw, GM; Lovingood, RV; Denny, TN; Haynes, B; Letvin, NL; Ferrari, G; Montefiori, DC; Tomaras, GD; Permar, SR; Center for HIV/AIDS Vaccine Immunology. HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies. Journal of Virology. 2011;85:9555-9567.  Abstract
  • Liao, HX; Chen, X; Munshaw, S; Zhang, R; Marshall, DJ; Vandergrift, N; Whitesides, JF; Lu, X; Yu, JS; Hwang, KK; Gao, F; Markowitz, M; Heath, SL; Bar, KJ; Goepfert, PA; Montefiori, DC; Shaw, GC; Alam, SM; Margolis, DM; Denny, TN; Boyd, SD; Marshal, E; Egholm, M; Simen, BB; Hanczaruk, B; Fire, AZ; Voss, G; Kelsoe, G; Tomaras, GD; Moody, MA; Kepler, TB; Haynes, BF. Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. Journal of Experimental Medicine. 2011;208:2237-2249.  Abstract
  • Mahlokozera, T; Kang, HH; Goonetilleke, N; Stacey, AR; Lovingood, RV; Denny, TN; Kalilani, L; Bunn, JE; Meshnick, SR; Borrow, P; Letvin, NL; Permar, SR; Center for HIV/AIDS Vaccine Immunology. The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk. PLoS One. 2011;6:e23735.  Abstract
  • Moody, MA; Zhang, R; Walter, EB; Woods, CW; Ginsburg, GS; McClain, MT; Denny, TN; Chen, X; Munshaw, S; Marshall, DJ; Whitesides, JF; Drinker, MS; Amos, JD; Gurley, TC; Eudailey, JA; Foulger, A; DeRosa, KR; Parks, R; Meyerhoff, RR; Yu, JS; Kozink, DM; Barefoot, BE; Ramsburg, EA; Khurana, S; Golding, H; Vandergrift, NA; Alam, SM; Tomaras, GD; Kepler, TB; Kelsoe, G; Liao, HX; Haynes, BF. H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination. PLoS One. 2011;6:e25797.  Abstract
  • Salazar-Gonzalez, JF; Salazar, MG; Learn, GH; Fouda, GG; Kang, HH; Mahlokozera, T; Wilks, AB; Lovingood, RV; Stacey, A; Kalilani, L; Meshnick, SR; Borrow, P; Montefiori, DC; Denny, TN; Letvin, NL; Shaw, GM; Hahn, BH; Permar, SR; Center for HIV/AIDS Vaccine Immunology A0167854. Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing. Journal of Virology. 2011;85:2751-2763.  Abstract
  • Yates, NL; Lucas, JT; Nolen, TL; Vandergrift, NA; Soderberg, KA; Seaton, KE; Denny, TN; Haynes, BF; Cohen, MS; Tomaras, GD. Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection. AIDS. 2011;25:2089-2097.  Abstract
  • Denny, TN; Louzao, R; Wong, J; Walker, B. CD4 T Cell Assessments in Evaluation of HIV Therapeutics. 2010;169-187.  
  • Freel, SA; Lamoreaux, L; Chattopadhyay, PK; Saunders, K; Zarkowsky, D; Overman, RG; Ochsenbauer, C; Edmonds, TG; Kappes, JC; Cunningham, CK; Denny, TN; Weinhold, KJ; Ferrari, G; Haynes, BF; Koup, RA; Graham, BS; Roederer, M; Tomaras, GD. Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination. Journal of Virology. 2010;84:4998-5006.  Abstract
  • Hultin, LE; Chow, M; Jamieson, BD; O'Gorman, MR; Menendez, FA; Borowski, L; Denny, TN; Margolick, JB. Comparison of interlaboratory variation in absolute T-cell counts by single-platform and optimized dual-platform methods. Cytometry Part B: Clinical Cytometry. 2010;78:194-200.  Abstract
  • Maecker, HT; McCoy, JP; Amos, M; Elliott, J; Gaigalas, A; Wang, L; Aranda, R; Banchereau, J; Boshoff, C; Braun, J; Korin, Y; Reed, E; Cho, J; Hafler, D; Davis, M; Fathman, CG; Robinson, W; Denny, T; Weinhold, K; Desai, B; Diamond, B; Gregersen, P; Dimeglio, P; Nestle, F; Peakman, M; Villnova, F; Ferbas, J; Field, E; Kantor, A; Kawabata, T; Komocsar, W; Lotze, M; Nepom, J; Ochs, H; O'Lone, R; Phippard, D; Plevy, S; Rich, S; Roederer, M; Rotrosen, D; Yeh, JH. A model for harmonizing flow cytometry in clinical trials. Nature Immunology. 2010;11:975-978.  
  • Moody, MA; Liao, HX; Alam, SM; Scearce, RM; Plonk, MK; Kozink, DM; Drinker, MS; Zhang, R; Xia, SM; Sutherland, LL; Tomaras, GD; Giles, IP; Kappes, JC; Ochsenbauer-Jambor, C; Edmonds, TG; Soares, M; Barbero, G; Forthal, DN; Landucci, G; Chang, C; King, SW; Kavlie, A; Denny, TN; Hwang, KK; Chen, PP; Thorpe, PE; Montefiori, DC; Haynes, BF. Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. Journal of Experimental Medicine. 2010;207:763-776.  Abstract
  • Freel, SA; Chattopadhyay, PK; Lamoreaux, L; Zarkowsky, D; Overman, RG; Ochsenbauer-Jambor, C; Kappes, JC; Cunningham, CK; Denny, TN; Weinhold, KJ; Ferrari, G; Koup, RA; Graham, BS; Haynes, BF; Roederer, M; Tomaras, GD. Phenotypic analyses of CD8+T cells that mediate virus inhibition from HIV-1 vaccinees and HIV-1+virus controllers. Retrovirology. 2009;6.  
  • Freel, SA; Chattopadhyay, PK; Lamoreaux, L; Zarkowsky, D; Overman, RG; Ochsenbauer-Jambor, C; Kappes, JC; Cunningham, CK; Denny, TN; Weinhold, KJ; Ferrari, G; Koup, RA; Graham, BS; Haynes, BF; Roederer, M; Tomaras, GD. S01-04 OA. Phenotypic analyses of CD8+ T cells that mediate virus inhibition from HIV-1 vaccinees and HIV-1+ virus controllers. Retrovirology. 2009;6:O1.  
  • Liao, HX; Levesque, MC; Nagel, A; Dixon, A; Zhang, R; Walter, E; Parks, R; Whitesides, J; Marshall, DJ; Hwang, KK; Yang, Y; Chen, X; Gao, F; Munshaw, S; Kepler, TB; Denny, T; Moody, MA; Haynes, BF. High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. Journal of Virological Methods. 2009;158:171-179.  Abstract
  • Liao, L; Chen, X; Dixon, A; Munshaw, S; Moody, M; Zhang, R; Nagel, A; Foulger, A; Derosa, K; Parks, R; Mcparland, M; Whitesides, J; Marshall, D; Amos, J; Yang, Y; Gao, F; Shea, T; Margolis, D; Shaw, G; Markowitz, M; Denny, T; Kelsoe, G; Tomaras, G; Kepler, T; Haynes, B. P04-45. Characterization of the plasma cell repertoire in acute HIV-1 infection (AHI). Retrovirology. 2009;6:P73.  
  • Plate, MM; Louzao, R; Steele, PM; Greengrass, V; Morris, LM; Lewis, J; Barnett, D; Warrino, D; Hearps, AC; Denny, T; Crowe, SM. Evaluation of the blood stabilizers transFix¿ and cyto-chex ® BCT for low-cost CD4 T-cell methodologies. Viral Immunology. 2009;22:329-332.  Abstract
  • Sarzotti-Kelsoe, M; Cox, J; Cleland, N; Denny, T; Hural, J; Needham, L; Ozaki, D; Rodriguez-Chavez, IR; Stevens, G; Stiles, T; Tarragona-Fiol, T; Simkins, A. Evaluation and recommendations on good clinical laboratory practice guidelines for phase I-III clinical trials. PLoS Medicine. 2009;6:e1000067.  Abstract
  • Sarzotti-Kelsoe, M; Cox, J; Cleland, N; Denny, T; Hural, J; Needham, L; Ozaki, D; Rodriguez-Chavez, IR; Stevens, G; Stiles, T; Tarragona-Fiol, T; Simkins, A. P15-05. Evaluation and recommendations on good clinical laboratory practice (GCLP) guidelines for phase I-III HIV vaccine clinical trials. Retrovirology. 2009;6:P206.  
  • Skinner, JA; Sharma, M; Baldwin, N; Lemoine, B; Blankenship, D; De Vol, EB; Mejias, A; Ramilo, O; Cohen, M; Letvin, N; Goldstein, D; Soderberg, K; Denny, TN; Shianna, K; McMichael, A; Haynes, B; Banchereau, J; Chaussabel, D. The blood transcriptional response to early acute HIV infection is transient and responsive to antiretroviral therapy. Retrovirology. 2009;6.  
  • Skinner, JA; Sharma, M; Baldwin, N; Lemoine, B; Blankenship, D; Vol, EBD; Mejias, A; Ramilo, O; Cohen, M; Letvin, N; Goldstein, D; Soderberg, K; Denny, TN; Shianna, K; McMichael, A; Haynes, B; Banchereau, J; Chaussabel, D. net P01-01. The blood transcriptional response to early acute HIV infection is transient and responsive to antiretroviral therapy. Retrovirology. 2009;6:P1.  
  • Stacey, A; Norris, P; Dibben, O; Qin, L; Cohen, M; Gay, C; Denny, T; Borrow, P. OA011-04. Striking elevations in systemic and mucosal cytokine and chemokine levels in acute HIV-1 infection. Retrovirology. 2009;6:O10.  
  • Barnett, D; Walker, B; Landay, A; Denny, TN. CD4 immunophenotyping in HIV infection. Nature Reviews Microbiology. 2008;6:S7-15.  Abstract
  • Denny, TN; Gelman, R; Bergeron, M; Landay, A; Lam, L; Louzao, R; Mandy, FF; Schmitz, J; Spira, T; Wilkening, C; Glencross, DK; NIAID-DAIDS Immunology Quality Assessment Program. A North American multilaboratory study of CD4 counts using flow cytometric panLeukogating (PLG): a NIAID-DAIDS Immunology Quality Assessment Program Study. Cytometry Part B: Clinical Cytometry. 2008;74 Suppl 1:S52-S64.  Abstract
  • Gasper-Smith, N; Crossman, DM; Whitesides, JF; Mensali, N; Ottinger, JS; Plonk, SG; Moody, MA; Ferrari, G; Weinhold, KJ; Miller, SE; Reich, CF; Qin, L; Self, SG; Shaw, GM; Denny, TN; Jones, LE; Pisetsky, DS; Haynes, BF. Induction of plasma (TRAIL), TNFR-2, Fas ligand, and plasma microparticles after human immunodeficiency virus type 1 (HIV-1) transmission: implications for HIV-1 vaccine design. Journal of Virology. 2008;82:7700-7710.  Abstract
  • Heinzen, EL; Ge, D; Cronin, KD; Maia, JM; Shianna, KV; Gabriel, WN; Welsh-Bohmer, KA; Hulette, CM; Denny, TN; Goldstein, DB. Tissue-specific genetic control of splicing: implications for the study of complex traits. PLoS Biology. 2008;6:e1.  Abstract
  • Merson, M; Denny, TN. The global health and diagnostic (flow) cytometry--breakthroughs in HIV and tuberculosis. Cytometry Part B: Clinical Cytometry. 2008;74 Suppl 1:S4-S5.  Abstract
  • Couch, RB; Winokur, P; Edwards, KM; Black, S; Atmar, RL; Stapleton, JT; Kissner, JM; Shinefield, H; Denny, TN; Bybel, MJ; Newman, FK; Yan, L; National Institute of Allergy and Infectious Diseases Smallpox Vaccine Study Group. Reducing the dose of smallpox vaccine reduces vaccine-associated morbidity without reducing vaccination success rates or immune responses. Journal of Infectious Diseases. 2007;195:826-832.  Abstract
  • Hultin, LE; Menendez, FA; Hultin, PM; Jamieson, BD; O'Gorman, MR; Borowski, L; Matud, JL; Denny, TN; Margolick, JB. Assessing immunophenotyping performance: proficiency-validation for adopting improved flow cytometry methods. Cytometry Part B: Clinical Cytometry. 2007;72:249-255.  Abstract
  • Weinberg, A; Louzao, R; Mussi-Pinhata, MM; Cruz, ML; Pinto, JA; Huff, MF; de Castro, AC; Sucupira, MC; Denny, TN. Quality assurance program for peripheral blood mononuclear cell cryopreservation. Clinical and Vaccine Immunology. 2007;14:1242-1244.  Abstract
  • Asthana, SP; Macpherson, CN; Weiss, SH; Stephens, R; Denny, TN; Sharma, RN; Dubey, JP. Seroprevalence of Toxoplasma gondii in pregnant women and cats in Grenada, West Indies. Journal of Parasitology. 2006;92:644-645.  Abstract
  • Dong, Y; Denny, TN. HLA-A2-restricted human CD8(+) cytotoxic T lymphocyte responses to a novel epitope in vaccinia virus that is conserved among orthopox viruses. Journal of Infectious Diseases. 2006;194:168-175.  Abstract
  • Sutton, MY; Holland, B; Denny, TN; Garcia, A; Garcia, Z; Stein, D; Bardeguez, AD. Effect of pregnancy and human immunodeficiency virus infection on intracellular interleukin-2 production patterns. Clinical and Vaccine Immunology. 2004;11:780-785.  Abstract
  • Rameshwar, P; Gascon, P; Oh, HS; Denny, TN; Zhu, G; Ganea, D. Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor. Experimental Hematology. 2002;30:1001-1009.  Abstract
  • Schmitz, JL; Denny, TN; Garcia, A; Lathey, JL; Adult and Pediatric AIDS Clinical Trials Group Immunology Laboratory Subcommittees. Comparison of human immunodeficiency virus antigens as stimulants for lymphocyte proliferation assays. Clinical and Vaccine Immunology. 2002;9:525-529.  Abstract
  • Rameshwar, P; Zhu, G; Donnelly, RJ; Qian, J; Ge, H; Goldstein, KR; Denny, TN; Gascón, P. The dynamics of bone marrow stromal cells in the proliferation of multipotent hematopoietic progenitors by substance P: an understanding of the effects of a neurotransmitter on the differentiating hematopoietic stem cell. Journal of Neuroimmunology. 2001;121:22-31.  Abstract
  • Siddiqi, M; Garcia, ZC; Stein, DS; Denny, TN; Spolarics, Z. Relationship between oxidative burst activity and CD11b expression in neutrophils and monocytes from healthy individuals: effects of race and gender. Cytometry. 2001;46:243-246.  Abstract