Mattia Bonsignori, MD

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Assistant Professor of Medicine
Department / Division:
Medicine / Medicine - DHVI Faculty
Address:
Room 4013, Msrb Ii
Durham, NC 27710
Office Telephone:
(919) 681-9739
Training:
  • MD, University of Insubria (Italy), 2001
Research Interests:
HIV vaccine development

Study of B-cell immune responses in HIV positive individuals

Determination of correlates of protective immunity to HIV

Induction of broadly neutralizing antibodies to HIV

Development of multiplex functional assays for the evaluation at a single-cell level of B-cell responses to vaccinations, infections and in vitro stimulation

Epidemiology and characterization of bacterial resistance determinants (past)
Representative Publications:
  • Bonsignori, M; Wiehe, K; Grimm, SK; Lynch, R; Yang, G; Kozink, DM; Perrin, F; Cooper, AJ; Hwang, KK; Chen, X; Liu, M; McKee, K; Parks, RJ; Eudailey, J; Wang, M; Clowse, M; Criscione-Schreiber, LG; Moody, MA; Ackerman, ME; Boyd, SD; Gao, F; Kelsoe, G; Verkoczy, L; Tomaras, GD; Liao, HX; Kepler, TB; Montefiori, DC; Mascola, JR; Haynes, BF. An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. Journal of Clinical Investigation. 2014;124:1835-1843.  Abstract
  • Pollara, J; Bonsignori, M; Moody, MA; Liu, P; Alam, SM; Hwang, KK; Gurley, TC; Kozink, DM; Armand, LC; Marshall, DJ; Whitesides, JF; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Robb, ML; O'Connell, RJ; Kim, JH; Michael, NL; Montefiori, DC; Tomaras, GD; Liao, HX; Haynes, BF; Ferrari, G. HIV-1 Vaccine-Induced C1 and V2 Env-Specific Antibodies Synergize for Increased Antiviral Activities. Journal of Virology. 2014;88:7715-7726.  Abstract
  • Alam, SM; Dennison, SM; Aussedat, B; Vohra, Y; Park, PK; Fern├índez-Tejada, A; Stewart, S; Jaeger, FH; Anasti, K; Blinn, JH; Kepler, TB; Bonsignori, M; Liao, HX; Sodroski, JG; Danishefsky, SJ; Haynes, BF. Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors. Proceedings of the National Academy of Sciences of USA. 2013;110:18214-18219.  Abstract
  • Liao, HX; Bonsignori, M; Alam, SM; McLellan, JS; Tomaras, GD; Moody, MA; Kozink, DM; Hwang, KK; Chen, X; Tsao, CY; Liu, P; Lu, X; Parks, RJ; Montefiori, DC; Ferrari, G; Pollara, J; Rao, M; Peachman, KK; Santra, S; Letvin, NL; Karasavvas, N; Yang, ZY; Dai, K; Pancera, M; Gorman, J; Wiehe, K; Nicely, NI; Rerks-Ngarm, S; Nitayaphan, S; Kaewkungwal, J; Pitisuttithum, P; Tartaglia, J; Sinangil, F; Kim, JH; Michael, NL; Kepler, TB; Kwong, PD; Mascola, JR; Nabel, GJ; Pinter, A; Zolla-Pazner, S; Haynes, BF. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity. 2013;38:176-186.  Abstract
  • Tomaras, GD; Ferrari, G; Shen, X; Alam, SM; Liao, HX; Pollara, J; Bonsignori, M; Moody, MA; Fong, Y; Chen, X; Poling, B; Nicholson, CO; Zhang, R; Lu, X; Parks, R; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Gilbert, PB; Kim, JH; Michael, NL; Montefiori, DC; Haynes, BF. Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. Proceedings of the National Academy of Sciences of USA. 2013;110:9019-9024.  Abstract
  • Bonsignori, M; Alam, SM; Liao, HX; Verkoczy, L; Tomaras, GD; Haynes, BF; Moody, MA. HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design. Trends in Microbiology. 2012;20:532-539.  Abstract
  • Bonsignori, M; Montefiori, DC; Wu, X; Chen, X; Hwang, KK; Tsao, CY; Kozink, DM; Parks, RJ; Tomaras, GD; Crump, JA; Kapiga, SH; Sam, NE; Kwong, PD; Kepler, TB; Liao, HX; Mascola, JR; Haynes, BF. Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design. Journal of Virology. 2012;86:4688-4692.  Abstract
  • Bonsignori, M; Pollara, J; Moody, MA; Alpert, MD; Chen, X; Hwang, KK; Gilbert, PB; Huang, Y; Gurley, TC; Kozink, DM; Marshall, DJ; Whitesides, JF; Tsao, CY; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Kim, JH; Michael, NL; Tomaras, GD; Montefiori, DC; Lewis, GK; DeVico, A; Evans, DT; Ferrari, G; Liao, HX; Haynes, BF. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. Journal of Virology. 2012;86:11521-11532.  Abstract
  • Bonsignori, M; Hwang, KK; Chen, X; Tsao, CY; Morris, L; Gray, E; Marshall, DJ; Crump, JA; Kapiga, SH; Sam, NE; Sinangil, F; Pancera, M; Yongping, Y; Zhang, B; Zhu, J; Kwong, PD; O'Dell, S; Mascola, JR; Wu, L; Nabel, GJ; Phogat, S; Seaman, MS; Whitesides, JF; Moody, MA; Kelsoe, G; Yang, X; Sodroski, J; Shaw, GM; Montefiori, DC; Kepler, TB; Tomaras, GD; Alam, SM; Liao, HX; Haynes, BF. Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors. Journal of Virology. 2011;85:9998-10009.  Abstract
  • McLellan, JS; Pancera, M; Carrico, C; Gorman, J; Julien, JP; Khayat, R; Louder, R; Pejchal, R; Sastry, M; Dai, K; O'Dell, S; Patel, N; Shahzad-ul-Hussan, S; Yang, Y; Zhang, B; Zhou, T; Zhu, J; Boyington, JC; Chuang, GY; Diwanji, D; Georgiev, I; Kwon, YD; Lee, D; Louder, MK; Moquin, S; Schmidt, SD; Yang, ZY; Bonsignori, M; Crump, JA; Kapiga, SH; Sam, NE; Haynes, BF; Burton, DR; Koff, WC; Walker, LM; Phogat, S; Wyatt, R; Orwenyo, J; Wang, LX; Arthos, J; Bewley, CA; Mascola, JR; Nabel, GJ; Schief, WR; Ward, AB; Wilson, IA; Kwong, PD. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature. 2011;480:336-343.  Abstract
  • Wu, X; Zhou, T; Zhu, J; Zhang, B; Georgiev, I; Wang, C; Chen, X; Longo, NS; Louder, M; McKee, K; O'Dell, S; Perfetto, S; Schmidt, SD; Shi, W; Wu, L; Yang, Y; Yang, ZY; Yang, Z; Zhang, Z; Bonsignori, M; Crump, JA; Kapiga, SH; Sam, NE; Haynes, BF; Simek, M; Burton, DR; Koff, WC; Doria-Rose, NA; Connors, M; NISC Comparative Sequencing Program, ; Mullikin, JC; Nabel, GJ; Roederer, M; Shapiro, L; Kwong, PD; Mascola, JR. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science. 2011;333:1593-1602.  Abstract
  • Bonsignori, M; Moody, MA; Parks, RJ; Holl, TM; Kelsoe, G; Hicks, CB; Vandergrift, N; Tomaras, GD; Haynes, BF. HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after envelope gp120 protein vaccination or HIV-1 infection. Journal of Immunology. 2009;183:2708-2717.  Abstract
  • Hurwitz, JL; Zhan, X; Brown, SA; Bonsignori, M; Stambas, J; Lockey, TD; Sealy, R; Surman, S; Freiden, P; Jones, B; Martin, L; Blanchard, J; Slobod, KS. HIV-1 vaccine development: tackling virus diversity with a multi-envelope cocktail. Frontiers in Bioscience. 2008;13:609-620.  Abstract