S. Munir Alam, PhD

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Professor in Medicine
Professor of Pathology
Department / Division:
Medicine / Medicine - DHVI Faculty
Address:
106 Research Drive
Msrb Ii Room 4004
Durham, NC 27710
Office Telephone:
(919) 668-6372
Training:
  • PhD, University of Glasgow (Scotland), 1992
Research Interests:
Research Interests.
Biophysical analysis of coreceptor modulation of TCR-MHC interactions. One of our research interests is to study the molecular mechanisms of T cell recognition. We have particular interest in understanding the trimolecular interactions between membrane bound T cell receptor (TCR-CD3 complex) and its ligand, the peptide-MHC complex (pMHC), and co-receptor molecules. We are using different biophysical approaches which include surface plasmon resonance, isothermal titration calorimetry and atomic force spectroscopy to study the influence of co-stimulatory molecules on the kinetics and thermodynamics of TCR-pMHC binding. The goal is to use integrated molecular and biophysical approaches to study membrane TCR-MHC interactions and to understand how these interactions are modulated by co-receptors during T cell development and activation.
Energetics and kinetics of monoclonal antibody binding to soluble HIV Envelope proteins. An additional interest of our lab involves biophysical characterization of soluble, recombinant human HIV-1 Envelope proteins (gp120 and gp140). We have employed surface plasmon resonance, analytical sedimentation equilibrium analysis, isothermal titration calorimetry and atomic force spectroscopy to characterize the antigenicity and study the energetics, kinetics and single molecule force measurements of the binding of anti-gp120 and anti-gp41 antibodies to several recombinant HIV-1 Envelope proteins. These studies have relevance in immunogen design for generating anti-HIV vaccines.
Representative Publications:
  • Dennison, SM; Anasti, KM; Jaeger, FH; Stewart, SM; Pollara, J; Liu, P; Kunz, EL; Zhang, R; Vandergrift, N; Permar, S; Ferrari, G; Tomaras, GD; Bonsignori, M; Michael, NL; Kim, JH; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Liao, HX; Haynes, BF; Alam, SM. Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide. Journal of Virology. 2014;88:9406-9417.  Abstract
  • Hardy, GJ; Wong, GC; Nayak, R; Anasti, K; Hirtz, M; Shapter, JG; Alam, SM; Zauscher, S. HIV-1 antibodies and vaccine antigen selectively interact with lipid domains. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 2014;1838:2662-2669.  Abstract
  • Holl, TM; Yang, G; Kuraoka, M; Verkoczy, L; Alam, SM; Moody, MA; Haynes, BF; Kelsoe, G. Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes. Journal of Immunology. 2014;192:3269-3279.  Abstract
  • Hu, B; Liao, H-X; Alam, SM; Goldstein, B. Estimating the Probability of Polyreactive Antibodies 4E10 and 2F5 Disabling a gp41 Trimer after T Cell-HIV Adhesion. PLoS Computational Biology. 2014;10.  
  • Hu, B; Liao, HX; Alam, SM; Goldstein, B. Estimating the probability of polyreactive antibodies 4E10 and 2F5 disabling a gp41 trimer after T cell-HIV adhesion. PLoS Computational Biology. 2014;10:e1003431.  Abstract
  • Kepler, TB; Munshaw, S; Wiehe, K; Zhang, R; Yu, JS; Woods, CW; Denny, TN; Tomaras, GD; Alam, SM; Moody, MA; Kelsoe, G; Liao, HX; Haynes, BF. Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation. Frontiers in Immunology. 2014;5:170.  Abstract
  • Lynch, HE; Stewart, SM; Kepler, TB; Sempowski, GD; Alam, SM. Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen. Journal of Immunological Methods. 2014;404:1-12.  
  • Lynch, HE; Stewart, SM; Kepler, TB; Sempowski, GD; Alam, SM. Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen. Journal of Immunological Methods. 2014;404:1-12.  
  • Lynch, HE; Stewart, SM; Kepler, TB; Sempowski, GD; Alam, SM. Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen. Journal of Immunological Methods. 2014;404:1-12.  Abstract
  • Moody, MA; Santra, S; Vandergrift, NA; Sutherland, LL; Gurley, TC; Drinker, MS; Allen, AA; Xia, SM; Meyerhoff, RR; Parks, R; Lloyd, KE; Easterhoff, D; Alam, SM; Liao, HX; Ward, BM; Ferrari, G; Montefiori, DC; Tomaras, GD; Seder, RA; Letvin, NL; Haynes, BF. Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques. Journal of Virology. 2014;88:3329-3339.  Abstract
  • Osuna, CE; Gonzalez, AM; Chang, HH; Hung, AS; Ehlinger, E; Anasti, K; Alam, SM; Letvin, NL. TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys. PLoS Pathogens. 2014;10:e1004069.  Abstract
  • Pollara, J; Bonsignori, M; Moody, MA; Liu, P; Alam, SM; Hwang, KK; Gurley, TC; Kozink, DM; Armand, LC; Marshall, DJ; Whitesides, JF; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Robb, ML; O'Connell, RJ; Kim, JH; Michael, NL; Montefiori, DC; Tomaras, GD; Liao, HX; Haynes, BF; Ferrari, G. HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities. Journal of Virology. 2014;88:7715-7726.  Abstract
  • Reardon, PN; Sage, H; Dennison, SM; Martin, JW; Donald, BR; Alam, SM; Haynes, BF; Spicer, LD. Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer. Proceedings of the National Academy of Sciences of USA. 2014;111:1391-1396.  Abstract
  • Roederer, M; Keele, BF; Schmidt, SD; Mason, RD; Welles, HC; Fischer, W; Labranche, C; Foulds, KE; Louder, MK; Yang, Z-Y; Todd, J-PM; Buzby, AP; Mach, LV; Shen, L; Seaton, KE; Ward, BM; Bailer, RT; Gottardo, R; Gu, W; Ferrari, G; Alam, SM; Denny, TN; Montefiori, DC; Tomaras, GD; Korber, BT; Nason, MC; Seder, RA; Koup, RA; Letvin, NL; Rao, SS; Nabel, GJ; Mascola, JR. Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature. 2014;505:502-508.  
  • Roederer, M; Keele, BF; Schmidt, SD; Mason, RD; Welles, HC; Fischer, W; Labranche, C; Foulds, KE; Louder, MK; Yang, ZY; Todd, JP; Buzby, AP; Mach, LV; Shen, L; Seaton, KE; Ward, BM; Bailer, RT; Gottardo, R; Gu, W; Ferrari, G; Alam, SM; Denny, TN; Montefiori, DC; Tomaras, GD; Korber, BT; Nason, MC; Seder, RA; Koup, RA; Letvin, NL; Rao, SS; Nabel, GJ; Mascola, JR. Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature. 2014;505:502-508.  Abstract
  • Trama, AM; Moody, MA; Alam, SM; Jaeger, FH; Lockwood, B; Parks, R; Lloyd, KE; Stolarchuk, C; Scearce, R; Foulger, A; Marshall, DJ; Whitesides, JF; Jeffries, TL; Wiehe, K; Morris, L; Lambson, B; Soderberg, K; Hwang, KK; Tomaras, GD; Vandergrift, N; Jackson, KJ; Roskin, KM; Boyd, SD; Kepler, TB; Liao, HX; Haynes, BF. HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria. Cell Host and Microbe. 2014;16:215-226.  Abstract
  • Yates, NL; Liao, HX; Fong, Y; deCamp, A; Vandergrift, NA; Williams, WT; Alam, SM; Ferrari, G; Yang, ZY; Seaton, KE; Berman, PW; Alpert, MD; Evans, DT; O'Connell, RJ; Francis, D; Sinangil, F; Lee, C; Nitayaphan, S; Rerks-Ngarm, S; Kaewkungwal, J; Pitisuttithum, P; Tartaglia, J; Pinter, A; Zolla-Pazner, S; Gilbert, PB; Nabel, GJ; Michael, NL; Kim, JH; Montefiori, DC; Haynes, BF; Tomaras, GD. Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination. Science Translational Medicine. 2014;6:228ra39.  Abstract
  • Zhang, J; Alam, SM; Bouton-Verville, H; Chen, Y; Newman, A; Stewart, S; Jaeger, FH; Montefiori, DC; Dennison, SM; Haynes, BF; Verkoczy, L. Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies. Journal of Immunology. 2014;192:1693-1706.  Abstract
  • Zhang, J; Alam, SM; Bouton-Verville, H; Chen, Y; Newman, A; Stewart, S; Jaeger, FH; Montefiori, DC; Dennison, SM; Haynes, BF; Verkoczy, L. Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies. Journal of Immunology. 2014;192:1693-1706.  
  • Alam, SM; Dennison, SM; Aussedat, B; Vohra, Y; Park, PK; Fern├índez-Tejada, A; Stewart, S; Jaeger, FH; Anasti, K; Blinn, JH; Kepler, TB; Bonsignori, M; Liao, HX; Sodroski, JG; Danishefsky, SJ; Haynes, BF. Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors. Proceedings of the National Academy of Sciences of USA. 2013;110:18214-18219.  Abstract
  • Alam, SM; Liao, HX; Tomaras, GD; Bonsignori, M; Tsao, CY; Hwang, KK; Chen, H; Lloyd, KE; Bowman, C; Sutherland, L; Jeffries, TL; Kozink, DM; Stewart, S; Anasti, K; Jaeger, FH; Parks, R; Yates, NL; Overman, RG; Sinangil, F; Berman, PW; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Karasavva, N; Rerks-Ngarm, S; Kim, JH; Michael, NL; Zolla-Pazner, S; Santra, S; Letvin, NL; Harrison, SC; Haynes, BF. Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion. Journal of Virology. 2013;87:1554-1568.  Abstract
  • Aussedat, B; Vohra, Y; Park, PK; Fern├índez-Tejada, A; Alam, SM; Dennison, SM; Jaeger, FH; Anasti, K; Stewart, S; Blinn, JH; Liao, HX; Sodroski, JG; Haynes, BF; Danishefsky, SJ. Chemical synthesis of highly congested gp120 V1V2 N-glycopeptide antigens for potential HIV-1-directed vaccines. Journal of the American Chemical Society. 2013;135:13113-13120.  Abstract
  • Chen, Y; Zhang, J; Bouton-Verville, H; Newman, A; Xia, S; Liao, H; Montefiori, DC; Moody, MA; Armand, L; Hwang, K; Lockwood, B; Dennison, SM; Alam, SM; Haynes, BF; Verkoczy, L. Lipid Components in MPER-Based Immunization Regimens Are Critical for Inducing Broadly Neutralizing Antibody Responses in 2F5 and 4E10 Knockin Mice. AIDS Research and Human Retroviruses. A20-A20.  
  • Fouda, GG; Jaeger, FH; Amos, JD; Ho, C; Kunz, EL; Anasti, K; Stamper, LW; Liebl, BE; Barbas, KH; Ohashi, T; Moseley, MA; Liao, HX; Erickson, HP; Alam, SM; Permar, SR. Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk. Proceedings of the National Academy of Sciences of USA. 2013;110:18220-18225.  Abstract
  • Fouda, GG; Mahlokozera, T; Salazar-Gonzalez, JF; Salazar, MG; Learn, G; Kumar, SB; Dennison, SM; Russell, E; Rizzolo, K; Jaeger, F; Cai, F; Vandergrift, NA; Gao, F; Hahn, B; Shaw, GM; Ochsenbauer, C; Swanstrom, R; Meshnick, S; Mwapasa, V; Kalilani, L; Fiscus, S; Montefiori, D; Haynes, B; Kwiek, J; Alam, SM; Permar, SR. Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants. Retrovirology. 2013;10:3.  Abstract
  • Gao, F; Bonsignori, M; Liao, H; Kumar, A; Xia, S; Cai, F; Lu, X; Kozink, DM; Kwong, P; Zhou, T; Lynch, R; Alam, SM; Ferrari, G; Kelsoe, G; Sandrasegaram, G; Shaw, GM; Hahn, BH; Montefiori, DC; Kamanga, G; Cohen, M; Braber, P; Korber, BT; Mascola, JR; Kepler, TB; Haynes, BF. Multiple Pathways of HIV-1 Autologous Neutralizing Antibodies Cooperate to Drive CD4 Binding Site Broadly Neutralizing Antibody Responses. AIDS Research and Human Retroviruses. A186-A186.  
  • Go, EP; Liao, H-X; Alam, SM; Hua, D; Haynes, BF; Desaire, H. Characterization of Host-Cell Line Specific Glycosylation Profiles of Early Transmitted/Founder HIV-1 gp120 Envelope Proteins. Journal of Proteome Research. 2013;12:1223-1234.  
  • Go, EP; Liao, HX; Alam, SM; Hua, D; Haynes, BF; Desaire, H. Characterization of host-cell line specific glycosylation profiles of early transmitted/founder HIV-1 gp120 envelope proteins. Journal of Proteome Research. 2013;12:1223-1234.  Abstract
  • Liao, HX; Bonsignori, M; Alam, SM; McLellan, JS; Tomaras, GD; Moody, MA; Kozink, DM; Hwang, KK; Chen, X; Tsao, CY; Liu, P; Lu, X; Parks, RJ; Montefiori, DC; Ferrari, G; Pollara, J; Rao, M; Peachman, KK; Santra, S; Letvin, NL; Karasavvas, N; Yang, ZY; Dai, K; Pancera, M; Gorman, J; Wiehe, K; Nicely, NI; Rerks-Ngarm, S; Nitayaphan, S; Kaewkungwal, J; Pitisuttithum, P; Tartaglia, J; Sinangil, F; Kim, JH; Michael, NL; Kepler, TB; Kwong, PD; Mascola, JR; Nabel, GJ; Pinter, A; Zolla-Pazner, S; Haynes, BF. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity. 2013;38:176-186.  Abstract
  • Liao, HX; Lynch, R; Zhou, T; Gao, F; Alam, SM; Boyd, SD; Fire, AZ; Roskin, KM; Schramm, CA; Zhang, Z; Zhu, J; Shapiro, L; NISC Comparative Sequencing Program, ; Mullikin, JC; Gnanakaran, S; Hraber, P; Wiehe, K; Kelsoe, G; Yang, G; Xia, SM; Montefiori, DC; Parks, R; Lloyd, KE; Scearce, RM; Soderberg, KA; Cohen, M; Kamanga, G; Louder, MK; Tran, LM; Chen, Y; Cai, F; Chen, S; Moquin, S; Du, X; Joyce, MG; Srivatsan, S; Zhang, B; Zheng, A; Shaw, GM; Hahn, BH; Kepler, TB; Korber, BT; Kwong, PD; Mascola, JR; Haynes, BF. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature. 2013;496:469-476.  Abstract
  • Liao, HX; Tsao, CY; Alam, SM; Muldoon, M; Vandergrift, N; Ma, BJ; Lu, X; Sutherland, LL; Scearce, RM; Bowman, C; Parks, R; Chen, H; Blinn, JH; Lapedes, A; Watson, S; Xia, SM; Foulger, A; Hahn, BH; Shaw, GM; Swanstrom, R; Montefiori, DC; Gao, F; Haynes, BF; Korber, B. Antigenicity and immunogenicity of transmitted/founder, consensus, and chronic envelope glycoproteins of human immunodeficiency virus type 1. Journal of Virology. 2013;87:4185-4201.  Abstract
  • Liu, P; Yates, NL; Shen, X; Bonsignori, M; Moody, MA; Liao, HX; Fong, Y; Alam, SM; Overman, RG; Denny, T; Ferrari, G; Ochsenbauer, C; Kappes, JC; Polonis, VR; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Rerks-Ngarm, S; Montefiori, DC; Gilbert, P; Michael, NL; Kim, JH; Haynes, BF; Tomaras, GD. Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees. Journal of Virology. 2013;87:7828-7836.  Abstract
  • Nicely, NI; Wiehe, K; Kepler, TB; Jaeger, FH; Dennison, SM; Liao, H; Alam, SM; Rerks-Ngarm, S; Nitayaphan, S; Pitisuttithum, P; Kaewkungwal, J; Michael, NL; Kim, JH; Haynes, BF. Structural Analysis of the Unmutated Common Ancestor Antibodies of the HIV Envelope V2 Antibodies CH58 and CH59 Derived from RV144 Vaccinees. AIDS Research and Human Retroviruses. A167-A168.  
  • Pancera, M; Shahzad-Ul-Hussan, S; Doria-Rose, NA; McLellan, JS; Bailer, RT; Dai, K; Loesgen, S; Louder, MK; Staupe, RP; Yang, Y; Zhang, B; Parks, R; Eudailey, J; Lloyd, KE; Blinn, J; Alam, SM; Haynes, BF; Amin, MN; Wang, LX; Burton, DR; Koff, WC; Nabel, GJ; Mascola, JR; Bewley, CA; Kwong, PD. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nature Structural and Molecular Biology. 2013;20:804-813.  
  • Pancera, M; Shahzad-Ul-Hussan, S; Doria-Rose, NA; McLellan, JS; Bailer, RT; Dai, K; Loesgen, S; Louder, MK; Staupe, RP; Yang, Y; Zhang, B; Parks, R; Eudailey, J; Lloyd, KE; Blinn, J; Alam, SM; Haynes, BF; Amin, MN; Wang, LX; Burton, DR; Koff, WC; Nabel, GJ; Mascola, JR; Bewley, CA; Kwong, PD. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nature Structural and Molecular Biology. 2013;20:804-813.  Abstract
  • Pegu, P; Vaccari, M; Gordon, S; Keele, BF; Doster, M; Guan, Y; Ferrari, G; Pal, R; Ferrari, MG; Whitney, S; Hudacik, L; Billings, E; Rao, M; Montefiori, D; Tomaras, G; Alam, SM; Fenizia, C; Lifson, JD; Stablein, D; Tartaglia, J; Michael, N; Kim, J; Venzon, D; Franchini, G. Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial. Journal of Virology. 2013;87:1708-1719.  Abstract
  • Tomaras, GD; Ferrari, G; Shen, X; Alam, SM; Liao, HX; Pollara, J; Bonsignori, M; Moody, MA; Fong, Y; Chen, X; Poling, B; Nicholson, CO; Zhang, R; Lu, X; Parks, R; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Gilbert, PB; Kim, JH; Michael, NL; Montefiori, DC; Haynes, BF. Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. Proceedings of the National Academy of Sciences of USA. 2013;110:9019-9024.  Abstract
  • Trama, AM; Liao, H; Jaeger, FH; Alam, SM; Wiehe, K; Jr, JTL; Foulger, A; Williams, WT; Marshall, DJ; Stolarchuk, C; Lloyd, KE; Parks, R; Soderberg, K; Kepler, TB; Vandergrift, N; Jackson, KJ; Fire, AZ; Boyd, SD; Whitesides, JF; Tomaras, GD; Moody, MA; Haynes, BF. Intestinal Commensal Bacteria Shape the Pre-transmission Antibody Repertoire to HIV-1 Infection. AIDS Research and Human Retroviruses. A105-A105.  
  • Verkoczy, L; Chen, Y; Zhang, J; Bouton-Verville, H; Newman, A; Lockwood, B; Scearce, RM; Montefiori, DC; Dennison, SM; Xia, SM; Hwang, KK; Liao, HX; Alam, SM; Haynes, BF. Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses. Journal of Immunology. 2013;191:2538-2550.  Abstract
  • Yang, G; Holl, TM; Liu, Y; Li, Y; Lu, X; Nicely, NI; Kepler, TB; Alam, SM; Liao, HX; Cain, DW; Spicer, L; VandeBerg, JL; Haynes, BF; Kelsoe, G. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. Journal of Experimental Medicine. 2013;210:241-256.  Abstract
  • Zhu, J; Ofek, G; Yang, Y; Zhang, B; Louder, MK; Lu, G; McKee, K; Pancera, M; Skinner, J; Zhang, Z; Parks, R; Eudailey, J; Lloyd, KE; Blinn, J; Alam, SM; Haynes, BF; Simek, M; Burton, DR; Koff, WC; NISC Comparative Sequencing Program, ; Mullikin, JC; Mascola, JR; Shapiro, L; Kwong, PD. Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains. Proceedings of the National Academy of Sciences of USA. 2013;110:6470-6475.  Abstract
  • Bonsignori, M; Alam, SM; Liao, HX; Verkoczy, L; Tomaras, GD; Haynes, BF; Moody, MA. HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design. Trends in Microbiology. 2012;20:532-539.  Abstract
  • Friedman, J; Alam, SM; Shen, X; Xia, SM; Stewart, S; Anasti, K; Pollara, J; Fouda, GG; Yang, G; Kelsoe, G; Ferrari, G; Tomaras, GD; Haynes, BF; Liao, HX; Moody, MA; Permar, SR. Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum. PLoS One. 2012;7:e37648.  Abstract
  • Hardy, GJ; Lam, Y; Stewart, SM; Anasti, K; Alam, SM; Zauscher, S. Screening the interactions between HIV-1 neutralizing antibodies and model lipid surfaces. Journal of Immunological Methods. 2012;376:13-19.  Abstract
  • Haynes, BF; Gilbert, PB; McElrath, MJ; Zolla-Pazner, S; Tomaras, GD; Alam, SM; Evans, DT; Montefiori, DC; Karnasuta, C; Sutthent, R; Liao, HX; DeVico, AL; Lewis, GK; Williams, C; Pinter, A; Fong, Y; Janes, H; DeCamp, A; Huang, Y; Rao, M; Billings, E; Karasavvas, N; Robb, ML; Ngauy, V; de Souza, MS; Paris, R; Ferrari, G; Bailer, RT; Soderberg, KA; Andrews, C; Berman, PW; Frahm, N; De Rosa, SC; Alpert, MD; Yates, NL; Shen, X; Koup, RA; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Rerks-Ngarm, S; Michael, NL; Kim, JH. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. New England Journal of Medicine. 2012;366:1275-1286.  Abstract
  • Huang, J; Ofek, G; Laub, L; Louder, MK; Doria-Rose, NA; Longo, NS; Imamichi, H; Bailer, RT; Chakrabarti, B; Sharma, SK; Alam, SM; Wang, T; Yang, Y; Zhang, B; Migueles, SA; Wyatt, R; Haynes, BF; Kwong, PD; Mascola, JR; Connors, M. Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature. 2012;491:406-412.  Abstract
  • Moody, MA; Yates, NL; Amos, JD; Drinker, MS; Eudailey, JA; Gurley, TC; Marshall, DJ; Whitesides, JF; Chen, X; Foulger, A; Yu, JS; Zhang, R; Meyerhoff, RR; Parks, R; Scull, JC; Wang, L; Vandergrift, NA; Pickeral, J; Pollara, J; Kelsoe, G; Alam, SM; Ferrari, G; Montefiori, DC; Voss, G; Liao, HX; Tomaras, GD; Haynes, BF. HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages. Journal of Virology. 2012;86:7496-7507.  Abstract
  • Petrovas, C; Yamamoto, T; Gerner, MY; Boswell, KL; Wloka, K; Smith, EC; Ambrozak, DR; Sandler, NG; Timmer, KJ; Sun, X; Pan, L; Poholek, A; Rao, SS; Brenchley, JM; Alam, SM; Tomaras, GD; Roederer, M; Douek, DC; Seder, RA; Germain, RN; Haddad, EK; Koup, RA. CD4 T follicular helper cell dynamics during SIV infection. Journal of Clinical Investigation. 2012;122:3281-3294.  Abstract
  • Bonsignori, M; Wu, X; Moody, MA; Liao, H; Hwang, K; Crump, JA; Capiga, SH; Sam, NE; Tomaras, GD; Chen, X; Tsao, C; Alam, SM; Nabel, GJ; Kwong, PD; Morris, L; Montefiori, D; Mascola, JR; Haynes, BF. Isolation of CD4-Binding Site and V2/V3 Conformational (Quaternary) Broadly Neutralizing Antibodies from the Same HIV-1 Infected African Subject. AIDS Research and Human Retroviruses. A120-A120.