Barton Ford Haynes, MD

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Professor of Medicine
Research Professor of Global Health
Professor of Immunology
Director of the Human Vaccine Institute in the Department of Medicine
Department / Division:
Medicine / Medicine-HVI-Haynes
Address:
106 Research Drive
Msrbii 4090
Durham, NC 27710
Office Telephone:
(919) 684-5384
Training:
  • MD, Baylor University, 1973
Research Interests:
The Haynes lab is studying host innate and adaptive immune responses to the human immunodeficiency virus (HIV), tuberculosis (TB), and influenza in order to find the enabling technology to make preventive vaccines against these three major infectious diseases.

Mucosal Immune Responses in Acute HIV Infection

The Haynes lab is working to determine why broadly neutralizing antibodies are rarely made in acute HIV infection (AHI), currently a major obstacle in the development of an HIV vaccine. The lab has developed a novel approach to define the B cell repertories in AHI in order to find neutralizing antibodies against the virus. This approach uses linear Immunoglobulin (Ig) heavy and light chain gene expression cassettes to express Ig V(H) and V(L) genes isolated from sorted single B cells as IgG1 antibody without a cloning step. This strategy was used to characterize the Ig repertoire of plasma cells/plasmablasts in AHI and to produce recombinant influenza mAbs from sorted single human plasmablasts after influenza vaccination.

The lab is also studying the earliest effect HIV-1 has on B cells. Analyzing blood and gut-associated lymphoid tissues (GALT) during acute HIV infection, they have found that as early as 17 days after transmission HIV-1 induces B cell class switching and 47 days after transmission, HIV-1 causes considerable damage to GALT germinal centers. They found that in AHI, GALT memory B cells induce polyclonal B cell activation due to the presence of HIV-1-specific, influenza-specific, and autoreactive antibodies. The team concluded from this study that early induction of polyclonal B cell differentiation, along with follicular damage and germinal center loss, may explain why HIV-1 induced antibody responses decline rapidly during acute HIV infection and why plasma antibody responses are delayed.

The lab is also looking at ways of generating long-lived memory B cell responses to HIV infection, another major hurdle in the development of a successful HIV-1 vaccine. The lab has found that in HIV-1 gp120 envelope vaccination and chronic HIV-1 infection, HIV-1 envelope induces predominantly short-lived memory B cell-dependent plasma antibodies.

Immunogen Design

To overcome the high level of genetic diversity in HIV-1 envelope genes, the Haynes lab is developing strategies to induce antibodies that cross-react with multiple strains of HIV. The lab has designed immunogens based on transmitted founder Envs and mosaic consensus Envs in collaboration with Dr. Bette Korber at Los Alamos National Laboratory. These immunogens are designed to induce antibodies that cross-react with a multiple subtype Env glycoproteins. The goal is to determine if cross-reactive mAbs to highly conserved epitopes in HIV-1 envelope glycoproteins can be induced. The team recently characterized a panel of ten mAbs that reacted with varying breadth to subtypes A, B, C, D, F, G, CRF01_AE, and a highly divergent SIVcpzUS Env protein. Two of the mAbs cross-reacted with all tested Env proteins, including SIVcpzUS Env and bound Env proteins with high affinity.

Mucosal Immune Responses in TB and Influenza

The Haynes lab is helping to develop novel approaches to TB vaccine development. The current therapeutic vaccine for TB, called BCG, may prevent complications from TB in children, but offers little protection against infection and disease in adults. The lab is focused on using live attenuated Mycobacterium tuberculosis mutants as vaccine candidates and is currently evaluating this approach in non-human primate studies. As part of the DHVI Influenza program, they are studying the B cell response to influenza in order to generate a “universal” flu vaccine. They are currently trying to express more highly conserved influenza antigens in recombinant vesicular stomatitis virus (rVSV) vectors in order to elicit robust T ce
Representative Publications:
  • Holl, TM; Yang, G; Kuraoka, M; Verkoczy, L; Alam, SM; Moody, MA; Haynes, BF; Kelsoe, G. Enhanced Antibody Responses to an HIV-1 Membrane-Proximal External Region Antigen in Mice Reconstituted with Cultured Lymphocytes. Journal of Immunology. 2014;192:3269-3279.  Abstract
  • Liu, P; Williams, LD; Shen, X; Bonsignori, M; Vandergrift, NA; Overman, RG; Moody, MA; Liao, HX; Stieh, DJ; McCotter, KL; French, AL; Hope, TJ; Shattock, R; Haynes, BF; Tomaras, GD. Capacity for Infectious HIV-1 Virion Capture Differs by Envelope Antibody Specificity. Journal of Virology. 2014;88:5165-5170.  Abstract
  • Moody, MA; Santra, S; Vandergrift, NA; Sutherland, LL; Gurley, TC; Drinker, MS; Allen, AA; Xia, SM; Meyerhoff, RR; Parks, R; Lloyd, KE; Easterhoff, D; Alam, SM; Liao, HX; Ward, BM; Ferrari, G; Montefiori, DC; Tomaras, GD; Seder, RA; Letvin, NL; Haynes, BF. Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques. Journal of Virology. 2014;88:3329-3339.  Abstract
  • Reardon, PN; Sage, H; Dennison, SM; Martin, JW; Donald, BR; Alam, SM; Haynes, BF; Spicer, LD. Structure of an HIV-1-neutralizing antibody target, the lipid-bound gp41 envelope membrane proximal region trimer. Proceedings of the National Academy of Sciences of USA. 2014;111:1391-1396.  Abstract
  • Zhang, J; Alam, SM; Bouton-Verville, H; Chen, Y; Newman, A; Stewart, S; Jaeger, FH; Montefiori, DC; Dennison, SM; Haynes, BF; Verkoczy, L. Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies. Journal of Immunology. 2014;192:1693-1706.  Abstract
  • Alam, SM; Dennison, SM; Aussedat, B; Vohra, Y; Park, PK; Fernández-Tejada, A; Stewart, S; Jaeger, FH; Anasti, K; Blinn, JH; Kepler, TB; Bonsignori, M; Liao, HX; Sodroski, JG; Danishefsky, SJ; Haynes, BF. Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors. Proceedings of the National Academy of Sciences of USA. 2013;110:18214-18219.  Abstract
  • Alam, SM; Liao, HX; Tomaras, GD; Bonsignori, M; Tsao, CY; Hwang, KK; Chen, H; Lloyd, KE; Bowman, C; Sutherland, L; Jeffries, TL; Kozink, DM; Stewart, S; Anasti, K; Jaeger, FH; Parks, R; Yates, NL; Overman, RG; Sinangil, F; Berman, PW; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Karasavva, N; Rerks-Ngarm, S; Kim, JH; Michael, NL; Zolla-Pazner, S; Santra, S; Letvin, NL; Harrison, SC; Haynes, BF. Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion. Journal of Virology. 2013;87:1554-1568.  Abstract
  • Alexander, J; Mendy, J; Vang, L; Avanzini, JB; Garduno, F; Manayani, DJ; Ishioka, G; Farness, P; Ping, LH; Swanstrom, R; Parks, R; Liao, HX; Haynes, BF; Montefiori, DC; LaBranche, C; Smith, J; Gurwith, M; Mayall, T. Pre-clinical development of a recombinant, replication-competent adenovirus serotype 4 vector vaccine expressing HIV-1 envelope 1086 clade C. PLoS One. 2013;8:e82380.  Abstract
  • Aussedat, B; Vohra, Y; Park, PK; Fernández-Tejada, A; Alam, SM; Dennison, SM; Jaeger, FH; Anasti, K; Stewart, S; Blinn, JH; Liao, HX; Sodroski, JG; Haynes, BF; Danishefsky, SJ. Chemical synthesis of highly congested gp120 V1V2 N-glycopeptide antigens for potential HIV-1-directed vaccines. Journal of the American Chemical Society. 2013;135:13113-13120.  Abstract
  • Baalwa, J; Wang, S; Parrish, NF; Decker, JM; Keele, BF; Learn, GH; Yue, L; Ruzagira, E; Ssemwanga, D; Kamali, A; Amornkul, PN; Price, MA; Kappes, JC; Karita, E; Kaleebu, P; Sanders, E; Gilmour, J; Allen, S; Hunter, E; Montefiori, DC; Haynes, BF; Cormier, E; Hahn, BH; Shaw, GM. Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clones. Virology. 2013;436:33-48.  
  • Baalwa, J; Wang, S; Parrish, NF; Decker, JM; Keele, BF; Learn, GH; Yue, L; Ruzagira, E; Ssemwanga, D; Kamali, A; Amornkul, PN; Price, MA; Kappes, JC; Karita, E; Kaleebu, P; Sanders, E; Gilmour, J; Allen, S; Hunter, E; Montefiori, DC; Haynes, BF; Cormier, E; Hahn, BH; Shaw, GM. Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clones. Virology. 2013;436:33-48.  Abstract
  • Chen, Y; Zhang, J; Hwang, KK; Bouton-Verville, H; Xia, SM; Newman, A; Ouyang, YB; Haynes, BF; Verkoczy, L. Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. Journal of Immunology. 2013;191:1260-1275.  Abstract
  • Fouda, GG; Amos, JD; Wilks, AB; Pollara, J; Ray, CA; Chand, A; Kunz, EL; Liebl, BE; Whitaker, K; Carville, A; Smith, S; Colvin, L; Pickup, DJ; Staats, HF; Overman, G; Eutsey-Lloyd, K; Parks, R; Chen, H; Labranche, C; Barnett, S; Tomaras, GD; Ferrari, G; Montefiori, DC; Liao, HX; Letvin, NL; Haynes, BF; Permar, SR. Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk. Journal of Virology. 2013;87:6986-6999.  Abstract
  • Fouda, GG; Mahlokozera, T; Salazar-Gonzalez, JF; Salazar, MG; Learn, G; Kumar, SB; Dennison, SM; Russell, E; Rizzolo, K; Jaeger, F; Cai, F; Vandergrift, NA; Gao, F; Hahn, B; Shaw, GM; Ochsenbauer, C; Swanstrom, R; Meshnick, S; Mwapasa, V; Kalilani, L; Fiscus, S; Montefiori, D; Haynes, B; Kwiek, J; Alam, SM; Permar, SR. Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants. Retrovirology. 2013;10:3.  Abstract
  • Go, EP; Liao, H-X; Alam, SM; Hua, D; Haynes, BF; Desaire, H. Characterization of Host-Cell Line Specific Glycosylation Profiles of Early Transmitted/Founder HIV-1 gp120 Envelope Proteins. Journal of Proteome Research. 2013;12:1223-1234.  
  • Go, EP; Liao, HX; Alam, SM; Hua, D; Haynes, BF; Desaire, H. Characterization of host-cell line specific glycosylation profiles of early transmitted/founder HIV-1 gp120 envelope proteins. Journal of Proteome Research. 2013;12:1223-1234.  Abstract
  • Gottardo, R; Bailer, RT; Korber, BT; Gnanakaran, S; Phillips, J; Shen, X; Tomaras, GD; Turk, E; Imholte, G; Eckler, L; Wenschuh, H; Zerweck, J; Greene, K; Gao, H; Berman, PW; Francis, D; Sinangil, F; Lee, C; Nitayaphan, S; Rerks-Ngarm, S; Kaewkungwal, J; Pitisuttithum, P; Tartaglia, J; Robb, ML; Michael, NL; Kim, JH; Zolla-Pazner, S; Haynes, BF; Mascola, JR; Self, S; Gilbert, P; Montefiori, DC. Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial. PLoS One. 2013;8:e75665.  Abstract
  • Haynes, BF; McElrath, MJ. Progress in HIV-1 vaccine development. Current Opinion in HIV and AIDS. 2013;8:326-332.  
  • Haynes, BF; McElrath, MJ. Progress in HIV-1 vaccine development. Current Opinion in HIV and AIDS. 2013;8:326-332.  Abstract
  • Klein, K; Veazey, RS; Warrier, R; Hraber, P; Doyle-Meyers, LA; Buffa, V; Liao, H-X; Haynes, BF; Shaw, GM; Shattock, RJ. Neutralizing IgG at the Portal of Infection Mediates Protection against Vaginal Simian/Human Immunodeficiency Virus Challenge. Journal of Virology. 2013;87:11604-11616.  Abstract
  • Klein, K; Veazey, RS; Warrier, R; Hraber, P; Doyle-Meyers, LA; Buffa, V; Liao, H-X; Haynes, BF; Shaw, GM; Shattock, RJ. Neutralizing igG at the portal of infection mediates protection against vaginal simian/human immunodeficiency virus challenge. Journal of Virology. 2013;87:11603-11616.  
  • Lambotte, O; Pollara, J; Boufassa, F; Moog, C; Venet, A; Haynes, BF; Delfraissy, JF; Saez-Cirion, A; Ferrari, G. High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers. PLoS One. 2013;8.  Abstract
  • Lane, J; McLaren, PJ; Dorrell, L; Shianna, KV; Stemke, A; Pelak, K; Moore, S; Oldenburg, J; Teresa Alvarez-Roman, M; Angelillo-Scherrer, A; Boehlen, F; Bolton-Maggs, PHB; Brand, B; Brown, D; Chiang, E; Rosa Cid-Haro, A; Clotet, B; Collins, P; Colombo, S; Dalmau, J; Fogarty, P; Giangrande, P; Gringeri, A; Iyer, R; Katsarou, O; Kempton, C; Kuriakose, P; Lin, J; Makris, M; Manco-Johnson, M; Tsakiris, DA; Martinez-Picado, J; Mauser-Bunschoten, E; Neff, A; Oka, S; Oyesiku, L; Parra, R; Peter-Salonen, K; Powell, J; Recht, M; Shapiro, A; Stine, K; Talks, K; Telenti, A; Wilde, J; Yee, TT; Wolinsky, SM; Martinson, J; Hussain, SK; Bream, JH; Jacobson, LP; Carrington, M; Goedert, JJ; Haynes, BF; McMichael, AJ; Goldstein, DB; Fellay, J; Vaccine, NIAIDCHIVAIDS. A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A (published). Human Molecular Genetics. 2013;22:1903-1910.  Abstract
  • Liao, HX; Bonsignori, M; Alam, SM; McLellan, JS; Tomaras, GD; Moody, MA; Kozink, DM; Hwang, KK; Chen, X; Tsao, CY; Liu, P; Lu, X; Parks, RJ; Montefiori, DC; Ferrari, G; Pollara, J; Rao, M; Peachman, KK; Santra, S; Letvin, NL; Karasavvas, N; Yang, ZY; Dai, K; Pancera, M; Gorman, J; Wiehe, K; Nicely, NI; Rerks-Ngarm, S; Nitayaphan, S; Kaewkungwal, J; Pitisuttithum, P; Tartaglia, J; Sinangil, F; Kim, JH; Michael, NL; Kepler, TB; Kwong, PD; Mascola, JR; Nabel, GJ; Pinter, A; Zolla-Pazner, S; Haynes, BF. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity. 2013;38:176-186.  Abstract
  • Liao, HX; Lynch, R; Zhou, T; Gao, F; Alam, SM; Boyd, SD; Fire, AZ; Roskin, KM; Schramm, CA; Zhang, Z; Zhu, J; Shapiro, L; NISC Comparative Sequencing Program, ; Mullikin, JC; Gnanakaran, S; Hraber, P; Wiehe, K; Kelsoe, G; Yang, G; Xia, SM; Montefiori, DC; Parks, R; Lloyd, KE; Scearce, RM; Soderberg, KA; Cohen, M; Kamanga, G; Louder, MK; Tran, LM; Chen, Y; Cai, F; Chen, S; Moquin, S; Du, X; Joyce, MG; Srivatsan, S; Zhang, B; Zheng, A; Shaw, GM; Hahn, BH; Kepler, TB; Korber, BT; Kwong, PD; Mascola, JR; Haynes, BF. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature. 2013;496:469-476.  Abstract
  • Liao, HX; Tsao, CY; Alam, SM; Muldoon, M; Vandergrift, N; Ma, BJ; Lu, X; Sutherland, LL; Scearce, RM; Bowman, C; Parks, R; Chen, H; Blinn, JH; Lapedes, A; Watson, S; Xia, SM; Foulger, A; Hahn, BH; Shaw, GM; Swanstrom, R; Montefiori, DC; Gao, F; Haynes, BF; Korber, B. Antigenicity and immunogenicity of transmitted/founder, consensus, and chronic envelope glycoproteins of human immunodeficiency virus type 1. Journal of Virology. 2013;87:4185-4201.  Abstract
  • Liu, MKP; Hawkins, N; Ritchie, AJ; Ganusov, VV; Whale, V; Brackenridge, S; Li, H; Pavlicek, JW; Cai, F; Rose-Abrahams, M; Treurnicht, F; Hraber, P; Riou, C; Gray, C; Ferrari, G; Tanner, R; Ping, L-H; Anderson, JA; Swanstrom, R; Chavi, CB; Cohen, M; Karim, SSA; Haynes, B; Borrow, P; Perelson, AS; Shaw, GM; Hahn, BH; Williamson, C; Korber, BT; Gao, F; Self, S; McMichael, A; Goonetilleke, N. Vertical T cell immunodominance and epitope entropy determine HIV-1 escape (published). Journal of Clinical Investigation. 2013;123:380-393.  Abstract
  • Liu, P; Yates, NL; Shen, X; Bonsignori, M; Moody, MA; Liao, HX; Fong, Y; Alam, SM; Overman, RG; Denny, T; Ferrari, G; Ochsenbauer, C; Kappes, JC; Polonis, VR; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Rerks-Ngarm, S; Montefiori, DC; Gilbert, P; Michael, NL; Kim, JH; Haynes, BF; Tomaras, GD. Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees. Journal of Virology. 2013;87:7828-7836.  Abstract
  • Mascola, JR; Haynes, BF. HIV-1 Neutralizing Antibodies: Understanding Nature's Pathways. Immunological Reviews. 2013;254:225-244.  Abstract
  • McMichael, AJ; Haynes, BF. Erratum: Lessons learned from HIV-1 vaccine trials: New priorities and directions (Nature Immunology (2012) 13 (423-427)). Nature Immunology. 2013;14:413-.  
  • McMichael, AJ; Haynes, BF. Influenza vaccines: MTOR inhibition surprisingly leads to protection. Nature Immunology. 2013;14:1205-1207.  Abstract
  • Pala, P; Serwanga, J; Watera, C; Ritchie, AJ; Moodie, Z; Wang, M; Goonetilleke, N; Birabwa, E; Hughes, P; Senkaali, D; Nakiboneka, R; Grosskurth, H; Haynes, B; McMichael, A; Kaleebu, P. Quantitative and qualitative differences in the T cell response to HIV in uninfected ugandans exposed or unexposed to HIV-infected partners. Journal of Virology. 2013;87:9053-9063.  Abstract
  • Pancera, M; Shahzad-Ul-Hussan, S; Doria-Rose, NA; McLellan, JS; Bailer, RT; Dai, K; Loesgen, S; Louder, MK; Staupe, RP; Yang, Y; Zhang, B; Parks, R; Eudailey, J; Lloyd, KE; Blinn, J; Alam, SM; Haynes, BF; Amin, MN; Wang, LX; Burton, DR; Koff, WC; Nabel, GJ; Mascola, JR; Bewley, CA; Kwong, PD. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nature Structural and Molecular Biology. 2013;20:804-813.  Abstract
  • Pancera, M; Shahzad-Ul-Hussan, S; Doria-Rose, NA; McLellan, JS; Bailer, RT; Dai, K; Loesgen, S; Louder, MK; Staupe, RP; Yang, Y; Zhang, B; Parks, R; Eudailey, J; Lloyd, KE; Blinn, J; Alam, SM; Haynes, BF; Amin, MN; Wang, LX; Burton, DR; Koff, WC; Nabel, GJ; Mascola, JR; Bewley, CA; Kwong, PD. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nature Structural and Molecular Biology. 2013;20:804-813.  
  • Parrish, NF; Gao, F; Li, H; Giorgi, EE; Barbian, HJ; Parrish, EH; Zajic, L; Iyer, SS; Decker, JM; Kumar, A; Hora, B; Berg, A; Cai, F; Hopper, J; Denny, TN; Ding, H; Ochsenbauer, C; Kappes, JC; Galimidi, RP; Jr, WAP; Bjorkman, PJ; Wilen, CB; Doms, RW; O'Brien, M; Bhardwaj, N; Borrow, P; Haynes, BF; Muldoon, M; Theiler, JP; Korber, B; Shaw, GM; Hahn, BH. Phenotypic properties of transmitted founder HIV-1 (published). Proceedings of the National Academy of Sciences of USA. 2013;110:6626-6633.  Abstract
  • Ping, L-H; Joseph, SB; Anderson, JA; Abrahams, M-R; Salazar-Gonzalez, JF; Kincer, LP; Treurnicht, FK; Arney, L; Ojeda, S; Zhang, M; Keys, J; Potter, EL; Chu, H; Moore, P; Salazar, MG; Iyer, S; Jabara, C; Kirchherr, J; Mapanje, C; Ngandu, N; Seoighe, C; Hoffman, I; Gao, F; Tang, Y; Labranche, C; Lee, B; Saville, A; Vermeulen, M; Fiscus, S; Morris, L; Karim, SA; Haynes, BF; Shaw, GM; Korber, BT; Hahn, BH; Cohen, MS; Montefiori, D; Williamson, C; Swanstrom, R; Team, CAPRISA0AIS; Immunology, CHIV-AIDSV. Comparison of Viral Env Proteins from Acute and Chronic Infections with Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences in Glycosylation and CCR5 Utilization and Suggests a New Strategy for Immunogen Design (published). Journal of Virology. 2013;87:7218-7233.  Abstract
  • Pollara, J; Bonsignori, M; Moody, MA; Pazgier, M; Haynes, BF; Ferrari, G. Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses. Current HIV Research. 2013;11:378-387.  Abstract
  • Schmidt, AG; Xu, H; Khan, AR; O'Donnell, T; Khurana, S; King, LR; Manischewitz, J; Golding, H; Suphaphiphat, P; Carfi, A; Settembre, EC; Dormitzer, PR; Kepler, TB; Zhang, R; Moody, MA; Haynes, BF; Liao, HX; Shaw, DE; Harrison, SC. Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proceedings of the National Academy of Sciences of USA. 2013;110:264-269.  Abstract
  • Tomaras, GD; Ferrari, G; Shen, X; Alam, SM; Liao, HX; Pollara, J; Bonsignori, M; Moody, MA; Fong, Y; Chen, X; Poling, B; Nicholson, CO; Zhang, R; Lu, X; Parks, R; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Gilbert, PB; Kim, JH; Michael, NL; Montefiori, DC; Haynes, BF. Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. Proceedings of the National Academy of Sciences of USA. 2013;110:9019-9024.  Abstract
  • Verkoczy, L; Chen, Y; Zhang, J; Bouton-Verville, H; Newman, A; Lockwood, B; Scearce, RM; Montefiori, DC; Dennison, SM; Xia, SM; Hwang, KK; Liao, HX; Alam, SM; Haynes, BF. Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses. Journal of Immunology. 2013;191:2538-2550.  Abstract
  • Yang, G; Holl, TM; Liu, Y; Li, Y; Lu, X; Nicely, NI; Kepler, TB; Alam, SM; Liao, HX; Cain, DW; Spicer, L; VandeBerg, JL; Haynes, BF; Kelsoe, G. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. Journal of Experimental Medicine. 2013;210:241-256.  Abstract
  • Yates, NL; Stacey, AR; Nolen, TL; Vandergrift, NA; Moody, MA; Montefiori, DC; Weinhold, KJ; Blattner, WA; Borrow, P; Shattock, R; Cohen, MS; Haynes, BF; Tomaras, GD. HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. Mucosal Immunology. 2013;6:692-703.  Abstract
  • Zhou, T; Zhu, J; Wu, X; Moquin, S; Zhang, B; Acharya, P; Georgiev, IS; Altae-Tran, HR; Chuang, GY; Joyce, MG; Do Kwon, Y; Longo, NS; Louder, MK; Luongo, T; McKee, K; Schramm, CA; Skinner, J; Yang, Y; Yang, Z; Zhang, Z; Zheng, A; Bonsignori, M; Haynes, BF; Scheid, JF; Nussenzweig, MC; Simek, M; Burton, DR; Koff, WC; NISC Comparative Sequencing Program, ; Mullikin, JC; Connors, M; Shapiro, L; Nabel, GJ; Mascola, JR; Kwong, PD. Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity. 2013;39:245-258.  Abstract
  • Zhu, J; Ofek, G; Yang, Y; Zhang, B; Louder, MK; Lu, G; McKee, K; Pancera, M; Skinner, J; Zhang, Z; Parks, R; Eudailey, J; Lloyd, KE; Blinn, J; Alam, SM; Haynes, BF; Simek, M; Burton, DR; Koff, WC; NISC Comparative Sequencing Program, ; Mullikin, JC; Mascola, JR; Shapiro, L; Kwong, PD. Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains. Proceedings of the National Academy of Sciences of USA. 2013;110:6470-6475.  Abstract
  • Zhu, Z; Qin, HR; Chen, W; Zhao, Q; Shen, X; Schutte, R; Wang, Y; Ofek, G; Streaker, E; Prabakaran, P; Fouda, GG; Liao, H-X; Owens, J; Louder, M; Yang, Y; Klaric, K-A; Anthony Moody, M; Mascola, JR; Scott, JK; Kwong, PD; Montefiori, D; Haynes, BF; Tomaras, GD; Dimitrov, DS. Erratum to Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies [Journal of Virology, 85, 21, (2011) 11401-11408] DOI: 10.1128/JVI.05312-11. Journal of Virology. 2013;87:13936-13936.  
  • Zhu, Z; Qin, HR; Chen, W; Zhao, Q; Shen, X; Schutte, R; Wang, Y; Ofek, G; Streaker, E; Prabakaran, P; Fouda, GG; Liao, H-X; Owens, J; Louder, M; Yang, Y; Klaric, K-A; Moody, MA; Mascola, JR; Scott, JK; Kwong, PD; Montefiori, D; Haynes, BF; Tomaras, GD; Dimitrov, DS. Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies (vol 85, pg 11401, 2011) (published). Journal of Virology. 2013;87:13936-13936.  
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  • Pollara, J; Hart, L; Brewer, F; Pickeral, J; Packard, BZ; Hoxie, JA; Komoriya, A; Ochsenbauer, C; Kappes, JC; Roederer, M; Huang, Y; Weinhold, KJ; Tomaras, GD; Haynes, BF; Montefiori, DC; Ferrari, G. High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses. Cytometry Part A. 2011;79:603-612.  Abstract
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  • Ritchie, AJ; Campion, SL; Kopycinski, J; Moodie, Z; Wang, ZM; Pandya, K; Moore, S; Liu, MK; Brackenridge, S; Kuldanek, K; Legg, K; Cohen, MS; Delwart, EL; Haynes, BF; Fidler, S; McMichael, AJ; Goonetilleke, N. Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals. Journal of Virology. 2011;85:3507-3516.  Abstract
  • Tang, H; Robinson, JE; Gnanakaran, S; Li, M; Rosenberg, ES; Perez, LG; Haynes, BF; Liao, HX; Labranche, CC; Korber, BT; Montefiori, DC. epitopes immediately below the base of the V3 loop of gp120 as targets for the initial autologous neutralizing antibody response in two HIV-1 subtype B-infected individuals. Journal of Virology. 2011;85:9286-9299.  Abstract
  • Tomaras, GD; Binley, JM; Gray, ES; Crooks, ET; Osawa, K; Moore, PL; Tumba, N; Tong, T; Shen, X; Yates, NL; Decker, J; Wibmer, CK; Gao, F; Alam, SM; Easterbrook, P; Abdool Karim, S; Kamanga, G; Crump, JA; Cohen, M; Shaw, GM; Mascola, JR; Haynes, BF; Montefiori, DC; Morris, L. Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals. Journal of Virology. 2011;85:11502-11519.  Abstract
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  • Verkoczy, L; Kelsoe, G; Moody, MA; Haynes, BF. Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies. Current Opinion in Immunology. 2011;23:383-390.  Abstract
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  • Wilen, CB; Parrish, NF; Pfaff, JM; Decker, JM; Henning, EA; Haim, H; Petersen, JE; Wojcechowskyj, JA; Sodroski, J; Haynes, BF; Montefiori, DC; Tilton, JC; Shaw, GM; Hahn, BH; Doms, RW. Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins. Journal of Virology. 2011;85:8514-8527.  Abstract
  • Wu, X; Zhou, T; Zhu, J; Zhang, B; Georgiev, I; Wang, C; Chen, X; Longo, NS; Louder, M; McKee, K; O'Dell, S; Perfetto, S; Schmidt, SD; Shi, W; Wu, L; Yang, Y; Yang, ZY; Yang, Z; Zhang, Z; Bonsignori, M; Crump, JA; Kapiga, SH; Sam, NE; Haynes, BF; Simek, M; Burton, DR; Koff, WC; Doria-Rose, NA; Connors, M; NISC Comparative Sequencing Program, ; Mullikin, JC; Nabel, GJ; Roederer, M; Shapiro, L; Kwong, PD; Mascola, JR. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science. 2011;333:1593-1602.  Abstract
  • Yates, NL; Lucas, JT; Nolen, TL; Vandergrift, NA; Soderberg, KA; Seaton, KE; Denny, TN; Haynes, BF; Cohen, MS; Tomaras, GD. Multiple HIV-1-specific IgG3 responses decline during acute HIV-1: implications for detection of incident HIV infection. AIDS. 2011;25:2089-2097.  Abstract
  • Yu, JS; Whitesides, J; Lee, SH; Taylor, N; Jacobs, WR; Letvin, NL; Haynes, BF. Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression. Clinical and Vaccine Immunology. 2011;18:43-49.  Abstract
  • Zhu, Z; Qin, HR; Chen, W; Zhao, Q; Shen, X; Schutte, R; Wang, Y; Ofek, G; Streaker, E; Prabakaran, P; Fouda, GG; Liao, HX; Owens, J; Louder, M; Yang, Y; Klaric, KA; Moody, MA; Mascola, JR; Scott, JK; Kwong, PD; Montefiori, D; Haynes, BF; Tomaras, GD; Dimitrov, DS. Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. Journal of Virology. 2011;85:11401-11408.  Abstract