M. Anthony Moody, MD

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Associate Professor of Pediatrics
Assistant Professor in the Department of Immunology
Department / Division:
Pediatrics / Pediatrics-Infectious Diseases
Address:
DUMC 3499
Durham, NC 27710
Appointment Telephone:
919-668-4000
Office Telephone:
919-684-6335
Training:
  • MD, Duke University School of Medicine, 1999
Residency:
  • Categorical Pediatrics, Emory University School of Medicine (Georgia), 1999-2002
  • Pediatrics, Chief Resident, Emory University School of Medicine (Georgia), 2002-2003
Fellowship:
  • Pediatric Infectious Diseases, Duke University School of Medicine, 2003-2006
Clinical Interests:
General pediatric infectious diseases, pediatric tuberculosis, sexually transmitted infections
Research Interests:
Tony Moody, MD is an Assistant Professor in the Department of Pediatrics, Division of Infectious Diseases at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza and dengue, and is interested in applying the technique to other disease processes.
Representative Publications:
  • Bonsignori, M; Wiehe, K; Grimm, SK; Lynch, R; Yang, G; Kozink, DM; Perrin, F; Cooper, AJ; Hwang, KK; Chen, X; Liu, M; McKee, K; Parks, RJ; Eudailey, J; Wang, M; Clowse, M; Criscione-Schreiber, LG; Moody, MA; Ackerman, ME; Boyd, SD; Gao, F; Kelsoe, G; Verkoczy, L; Tomaras, GD; Liao, HX; Kepler, TB; Montefiori, DC; Mascola, JR; Haynes, BF. An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. Journal of Clinical Investigation. 2014;124:1835-1843.  Abstract
  • Garcia, A; Keinonen, S; Sanchez, AM; Ferrari, G; Denny, TN; Moody, MA. Leukopak PBMC sample processing for preparing quality control material to support proficiency testing programs. Journal of Immunological Methods. 2014;409:99-106.  Abstract
  • Haynes, BF; Moody, MA; Alam, M; Bonsignori, M; Verkoczy, L; Ferrari, G; Gao, F; Tomaras, GD; Liao, HX; Kelsoe, G. Progress in HIV-1 vaccine development. Journal of Allergy and Clinical Immunology. 2014;134:3-10.  Abstract
  • Holl, TM; Yang, G; Kuraoka, M; Verkoczy, L; Alam, SM; Moody, MA; Haynes, BF; Kelsoe, G. Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes. Journal of Immunology. 2014;192:3269-3279.  Abstract
  • Jackson, KJ; Liu, Y; Roskin, KM; Glanville, J; Hoh, RA; Seo, K; Marshall, EL; Gurley, TC; Moody, MA; Haynes, BF; Walter, EB; Liao, HX; Albrecht, RA; García-Sastre, A; Chaparro-Riggers, J; Rajpal, A; Pons, J; Simen, BB; Hanczaruk, B; Dekker, CL; Laserson, J; Koller, D; Davis, MM; Fire, AZ; Boyd, SD. Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements. Cell Host and Microbe. 2014;16:105-114.  Abstract
  • Kepler, TB; Munshaw, S; Wiehe, K; Zhang, R; Yu, JS; Woods, CW; Denny, TN; Tomaras, GD; Alam, SM; Moody, MA; Kelsoe, G; Liao, HX; Haynes, BF. Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation. Frontiers in Immunology. 2014;5:170.  Abstract
  • Liu, P; Williams, LD; Shen, X; Bonsignori, M; Vandergrift, NA; Overman, RG; Moody, MA; Liao, HX; Stieh, DJ; McCotter, KL; French, AL; Hope, TJ; Shattock, R; Haynes, BF; Tomaras, GD. Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. Journal of Virology. 2014;88:5165-5170.  Abstract
  • Madani, N; Princiotto, AM; Schön, A; LaLonde, J; Feng, Y; Freire, E; Park, J; Courter, JR; Jones, DM; Robinson, J; Liao, HX; Moody, MA; Permar, S; Haynes, B; Smith, AB; Wyatt, R; Sodroski, J. CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus to Vaccine-Elicited Antibodies. Journal of Virology. 2014;88:6542-6555.  Abstract
  • Moody, MA. Modulation of HIV-1 immunity by adjuvants. Current Opinion in HIV and AIDS. 2014;9:242-249.  Abstract
  • Moody, MA; Santra, S; Vandergrift, NA; Sutherland, LL; Gurley, TC; Drinker, MS; Allen, AA; Xia, SM; Meyerhoff, RR; Parks, R; Lloyd, KE; Easterhoff, D; Alam, SM; Liao, HX; Ward, BM; Ferrari, G; Montefiori, DC; Tomaras, GD; Seder, RA; Letvin, NL; Haynes, BF. Toll-like receptor 7/8 (TLR7/8) and TLR9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques. Journal of Virology. 2014;88:3329-3339.  Abstract
  • Pollara, J; Bonsignori, M; Moody, MA; Liu, P; Alam, SM; Hwang, KK; Gurley, TC; Kozink, DM; Armand, LC; Marshall, DJ; Whitesides, JF; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Robb, ML; O'Connell, RJ; Kim, JH; Michael, NL; Montefiori, DC; Tomaras, GD; Liao, HX; Haynes, BF; Ferrari, G. HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities. Journal of Virology. 2014;88:7715-7726.  Abstract
  • Amos, JD; Wilks, AB; Fouda, GG; Smith, SD; Colvin, L; Mahlokozera, T; Ho, C; Beck, K; Overman, RG; DeMarco, CT; Hodge, TL; LaBranche, CC; Montefiori, DC; Denny, TN; Liao, HX; Tomaras, GD; Moody, MA; Permar, SR. Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys. Journal of Virology. 2013;87:11121-11134.  Abstract
  • Apps, R; Qi, Y; Carlson, JM; Chen, H; Gao, X; Thomas, R; Yuki, Y; Del Prete, GQ; Goulder, P; Brumme, ZL; Brumme, CJ; John, M; Mallal, S; Nelson, G; Bosch, R; Heckerman, D; Stein, JL; Soderberg, KA; Moody, MA; Denny, TN; Zeng, X; Fang, J; Moffett, A; Lifson, JD; Goedert, JJ; Buchbinder, S; Kirk, GD; Fellay, J; McLaren, P; Deeks, SG; Pereyra, F; Walker, B; Michael, NL; Weintrob, A; Wolinsky, S; Liao, W; Carrington, M. Influence of HLA-C Expression Level on HIV Control. Science. 2013;340:87-91.  Abstract
  • Bonsignori, M; Wiehe, K; Lynch, RM; Grimm, SK; Kozink, DM; Hwang, K; Eudailey, JA; Yang, G; Ackerman, ME; Kelsoe, G; Liao, H; Moody, MA; Kepler, TB; Montefiori, DC; Mascola, JR; Haynes, BF. Isolation and Characterization of an Autoreactive CD4bs Broad Neutralizing Antibody from a Chronic HIV-1 Controller with Systemic Lupus Erythematosus. AIDS Research and Human Retroviruses. A45-A46.  
  • Chen, Y; Zhang, J; Bouton-Verville, H; Newman, A; Xia, S; Liao, H; Montefiori, DC; Moody, MA; Armand, L; Hwang, K; Lockwood, B; Dennison, SM; Alam, SM; Haynes, BF; Verkoczy, L. Lipid Components in MPER-Based Immunization Regimens Are Critical for Inducing Broadly Neutralizing Antibody Responses in 2F5 and 4E10 Knockin Mice. AIDS Research and Human Retroviruses. A20-A20.  
  • Kunz, E; Fouda, G; Ho, C; Amos, J; Colvin, L; Montefiori, D; Martelli, A; Allen, A; Aramand, L; Marshall, DJ; Letvin, NL; Staats, H; Pickup, D; Barnett, SC; Moody, MA; Haynes, BF; Liao, H; Permar, SR. Combined Mucosal and Systemic C.1086 Envelope Immunization of Lactating Monkeys Induces Potent IgA and Functional IgG Antibody Responses in Milk. AIDS Research and Human Retroviruses. A180-A180.  
  • Liao, HX; Bonsignori, M; Alam, SM; McLellan, JS; Tomaras, GD; Moody, MA; Kozink, DM; Hwang, KK; Chen, X; Tsao, CY; Liu, P; Lu, X; Parks, RJ; Montefiori, DC; Ferrari, G; Pollara, J; Rao, M; Peachman, KK; Santra, S; Letvin, NL; Karasavvas, N; Yang, ZY; Dai, K; Pancera, M; Gorman, J; Wiehe, K; Nicely, NI; Rerks-Ngarm, S; Nitayaphan, S; Kaewkungwal, J; Pitisuttithum, P; Tartaglia, J; Sinangil, F; Kim, JH; Michael, NL; Kepler, TB; Kwong, PD; Mascola, JR; Nabel, GJ; Pinter, A; Zolla-Pazner, S; Haynes, BF. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity. 2013;38:176-186.  Abstract
  • Liu, P; Yates, NL; Shen, X; Bonsignori, M; Moody, MA; Liao, HX; Fong, Y; Alam, SM; Overman, RG; Denny, T; Ferrari, G; Ochsenbauer, C; Kappes, JC; Polonis, VR; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Rerks-Ngarm, S; Montefiori, DC; Gilbert, P; Michael, NL; Kim, JH; Haynes, BF; Tomaras, GD. Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees. Journal of Virology. 2013;87:7828-7836.  Abstract
  • McWilliams, L; Su, KY; Liang, X; Liao, D; Floyd, S; Amos, J; Moody, MA; Kelsoe, G; Kuraoka, M. The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors. Journal of Leukocyte Biology. 2013;94:991-1001.  Abstract
  • Pollara, J; Bonsignori, M; Moody, MA; Pazgier, M; Haynes, BF; Ferrari, G. Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses. Current HIV Research. 2013;11:378-387.  Abstract
  • Sacha, CR; Vandergrift, N; Marshall, DJ; Gurley, TC; Stiegel, L; Whitesides, JF; Friedman, J; Fouda, GG; Liebl, B; McGuire, E; Foulger, A; Kepler, TB; Liao, H; Haynes, BF; Moody, MA; Permar, SR. Distinct VH Gene Usage and HIV Envelope Specificity of Colostrum and Peripheral B Cell Monoclonal Antibodies of HIV-Infected, Lactating African Women. AIDS Research and Human Retroviruses. A169-A170.  
  • Schmidt, AG; Xu, H; Khan, AR; O'Donnell, T; Khurana, S; King, LR; Manischewitz, J; Golding, H; Suphaphiphat, P; Carfi, A; Settembre, EC; Dormitzer, PR; Kepler, TB; Zhang, R; Moody, MA; Haynes, BF; Liao, HX; Shaw, DE; Harrison, SC. Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proceedings of the National Academy of Sciences of USA. 2013;110:264-269.  Abstract
  • Su, K-Y; Nojima, T; Kuraoka, M; Moody, MA; Kelsoe, G. An in vitro culture system for studying the human B cell repertoire. Journal of Immunology.  
  • Tomaras, GD; Ferrari, G; Shen, X; Alam, SM; Liao, HX; Pollara, J; Bonsignori, M; Moody, MA; Fong, Y; Chen, X; Poling, B; Nicholson, CO; Zhang, R; Lu, X; Parks, R; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Gilbert, PB; Kim, JH; Michael, NL; Montefiori, DC; Haynes, BF. Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. Proceedings of the National Academy of Sciences of USA. 2013;110:9019-9024.  Abstract
  • Trama, AM; Liao, H; Jaeger, FH; Alam, SM; Wiehe, K; Jr, JTL; Foulger, A; Williams, WT; Marshall, DJ; Stolarchuk, C; Lloyd, KE; Parks, R; Soderberg, K; Kepler, TB; Vandergrift, N; Jackson, KJ; Fire, AZ; Boyd, SD; Whitesides, JF; Tomaras, GD; Moody, MA; Haynes, BF. Intestinal Commensal Bacteria Shape the Pre-transmission Antibody Repertoire to HIV-1 Infection. AIDS Research and Human Retroviruses. A105-A105.  
  • Williams, WB; Jones, K; Liu, P; Trama, AM; Seaton, K; Moody, MA; Vandergrift, N; Wiehe, K; Liao, H; Montefiori, DC; Ochsenbauer, C; Kappes, J; Hammer, SM; Mascola, J; Koup, R; Corey, L; Nabel, G; Gilbert, P; Morgan, CA; Churchyard, G; Maenza, J; Baden, LR; Keefer, M; Graham, BS; Tomaras, GD; Haynes, BF. Antibody Repertoire Induced by the Multiclade (Env A, B, C) HIV-1 DNA Prime, rAd5 Boost VRC Vaccine. AIDS Research and Human Retroviruses. A9-A9.  
  • Yates, NL; Stacey, AR; Nolen, TL; Vandergrift, NA; Moody, MA; Montefiori, DC; Weinhold, KJ; Blattner, WA; Borrow, P; Shattock, R; Cohen, MS; Haynes, BF; Tomaras, GD. HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life. Mucosal Immunology. 2013;6:692-703.  Abstract
  • Zhu, Z; Qin, HR; Chen, W; Zhao, Q; Shen, X; Schutte, R; Wang, Y; Ofek, G; Streaker, E; Prabakaran, P; Fouda, GG; Liao, H-X; Owens, J; Louder, M; Yang, Y; Klaric, K-A; Anthony Moody, M; Mascola, JR; Scott, JK; Kwong, PD; Montefiori, D; Haynes, BF; Tomaras, GD; Dimitrov, DS. Erratum to Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies [Journal of Virology, 85, 21, (2011) 11401-11408] DOI: 10.1128/JVI.05312-11. Journal of Virology. 2013;87:13936-13936.  
  • Zhu, Z; Qin, HR; Chen, W; Zhao, Q; Shen, X; Schutte, R; Wang, Y; Ofek, G; Streaker, E; Prabakaran, P; Fouda, GG; Liao, H-X; Owens, J; Louder, M; Yang, Y; Klaric, K-A; Moody, MA; Mascola, JR; Scott, JK; Kwong, PD; Montefiori, D; Haynes, BF; Tomaras, GD; Dimitrov, DS. Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies (vol 85, pg 11401, 2011). Journal of Virology. 2013;87:13936-13936.  
  • Amos, JD; Wilks, AB; Fouda, GG; Smith, SD; Overman, GR; Beck, K; Moody, MA; Tomaras, GD; Permar, SR. Strong SIV gp120-specific IgG/IgA responses in milk of African green monkeys may contribute to the rarity of postnatal transmission in this species. Retrovirology. 2012;9.  
  • Bonsignori, M; Alam, SM; Liao, HX; Verkoczy, L; Tomaras, GD; Haynes, BF; Moody, MA. HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design. Trends in Microbiology. 2012;20:532-539.  Abstract
  • Bonsignori, M; Pollara, J; Moody, MA; Alpert, MD; Chen, X; Hwang, KK; Gilbert, PB; Huang, Y; Gurley, TC; Kozink, DM; Marshall, DJ; Whitesides, JF; Tsao, CY; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Kim, JH; Michael, NL; Tomaras, GD; Montefiori, DC; Lewis, GK; DeVico, A; Evans, DT; Ferrari, G; Liao, HX; Haynes, BF. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. Journal of Virology. 2012;86:11521-11532.  Abstract
  • Bonsignori, M; Pollara, J; Moody, MA; Kepler, TB; Chen, X; Gurley, TC; Kozink, DM; Marshall, DJ; Whitesides, JF; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Kim, JH; Michael, NL; Montefiori, DC; Liao, H; Ferrari, G; Haynes, BF. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial preferentially use the VH1 gene family. Retrovirology. 2012;9.  
  • Friedman, J; Alam, SM; Shen, X; Xia, SM; Stewart, S; Anasti, K; Pollara, J; Fouda, GG; Yang, G; Kelsoe, G; Ferrari, G; Tomaras, GD; Haynes, BF; Liao, HX; Moody, MA; Permar, SR. Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum. PLoS One. 2012;7:e37648.  Abstract
  • Li, L; Wang, XH; Banerjee, S; Volsky, B; Williams, C; Moody, MA; Zolla-Pazner, S; Gorny, MK. Clonal analysis of human anti-V3 monoclonal antibodies selected by a V3 tetramer. Human Antibodies. 2012;21:65-73.  
  • Montefiori, DC; Karnasuta, C; Huang, Y; Ahmed, H; Gilbert, P; de Souza, MS; McLinden, R; Tovanabutra, S; Laurence-Chenine, A; Sanders-Buell, E; Moody, MA; Bonsignori, M; Ochsenbauer, C; Kappes, J; Tang, H; Greene, K; Gao, H; LaBranche, CC; Andrews, C; Polonis, VR; Rerks-Ngarm, S; Pitisuttithum, P; Nitayaphan, S; Kaewkungwal, J; Self, SG; Berman, PW; Francis, D; Sinangil, F; Lee, C; Tartaglia, J; Robb, ML; Haynes, BF; Michael, NL; Kim, JH. Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials. Journal of Infectious Diseases. 2012;206:431-441.  Abstract
  • Moody, MA; Yates, NL; Amos, JD; Drinker, MS; Eudailey, JA; Gurley, TC; Marshall, DJ; Whitesides, JF; Chen, X; Foulger, A; Yu, JS; Zhang, R; Meyerhoff, RR; Parks, R; Scull, JC; Wang, L; Vandergrift, NA; Pickeral, J; Pollara, J; Kelsoe, G; Alam, SM; Ferrari, G; Montefiori, DC; Voss, G; Liao, HX; Tomaras, GD; Haynes, BF. HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages. Journal of Virology. 2012;86:7496-7507.  Abstract
  • Song, H; Pavlicek, JW; Cai, F; Bhattacharya, T; Li, H; Iyer, SS; Bar, KJ; Decker, JM; Goonetilleke, N; Liu, MK; Berg, A; Hora, B; Drinker, MS; Eudailey, J; Pickeral, J; Moody, MA; Ferrari, G; McMichael, A; Perelson, AS; Shaw, GM; Hahn, BH; Haynes, BF; Gao, F. Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome. Retrovirology. 2012;9:89.  Abstract
  • Thomas, R; Thio, CL; Apps, R; Qi, Y; Gao, X; Marti, D; Stein, JL; Soderberg, KA; Moody, MA; Goedert, JJ; Kirk, GD; Hoots, WK; Wolinsky, S; Carrington, M. A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection. Journal of Virology. 2012;86:6979-6985.  Abstract
  • Trama, AM; Liao, H; Foulger, A; Marshall, DJ; Whitesides, JF; Parks, R; Meyerhoff, R; Lloyd, KE; Donathan, M; Lucas, J; Soderberg, K; Kepler, TB; Vandergrift, N; Yates, N; Tomaras, GD; Moody, MA; Haynes, BF. Lack of IgA envelope-reactive antibody producing cells in terminal ileum in early and chronic HIV-1 infection. Retrovirology. 2012;9.  
  • Williams, WB; Jones, K; Krambrink, A; Grove, D; Liu, P; Yates, NL; Moody, MA; Ferrari, G; Pollara, J; Moodie, Z; Morgan, CA; Liao, H; Montefiori, DC; Ochsenbauer, C; Kappes, J; Hammer, S; Mascola, J; Koup, R; Corey, L; Nabel, G; Gilbert, P; Churchyard, G; Keefer, M; Graham, BS; Haynes, BF; Tomaras, GD. Multiple antibody specificities (gp41, V1V2, and V3) elicited in the phase II multiclade (A, B, C) HIV-1 DNA prime, rAd5 boost vaccine trial. Retrovirology. 2012;9.  
  • Bonsignori, M; Hwang, KK; Chen, X; Tsao, CY; Morris, L; Gray, E; Marshall, DJ; Crump, JA; Kapiga, SH; Sam, NE; Sinangil, F; Pancera, M; Yongping, Y; Zhang, B; Zhu, J; Kwong, PD; O'Dell, S; Mascola, JR; Wu, L; Nabel, GJ; Phogat, S; Seaman, MS; Whitesides, JF; Moody, MA; Kelsoe, G; Yang, X; Sodroski, J; Shaw, GM; Montefiori, DC; Kepler, TB; Tomaras, GD; Alam, SM; Liao, HX; Haynes, BF. Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors. Journal of Virology. 2011;85:9998-10009.  Abstract
  • Ferrari, G; Pollara, J; Kozink, D; Harms, T; Drinker, M; Freel, S; Moody, MA; Alam, SM; Tomaras, GD; Ochsenbauer, C; Kappes, JC; Shaw, GM; Hoxie, JA; Robinson, JE; Haynes, BF. An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum. Journal of Virology. 2011;85:7029-7036.  Abstract
  • Gray, ES; Moody, MA; Wibmer, CK; Chen, X; Marshall, D; Amos, J; Moore, PL; Foulger, A; Yu, JS; Lambson, B; Abdool Karim, S; Whitesides, J; Tomaras, GD; Haynes, BF; Morris, L; Liao, HX. Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individual. Journal of Virology. 2011;85:7719-7729.  Abstract
  • Haynes, BF; Moody, MA; Liao, HX; Verkoczy, L; Tomaras, GD. B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends in Molecular Medicine. 2011;17:108-116.  Abstract
  • Jiang, C; Parrish, NF; Wilen, CB; Li, H; Chen, Y; Pavlicek, JW; Berg, A; Lu, X; Song, H; Tilton, JC; Pfaff, JM; Henning, EA; Decker, JM; Moody, MA; Drinker, MS; Schutte, R; Freel, S; Tomaras, GD; Nedellec, R; Mosier, DE; Haynes, BF; Shaw, GM; Hahn, BH; Doms, RW; Gao, F. Primary infection by a human immunodeficiency virus with atypical coreceptor tropism. Journal of Virology. 2011;85:10669-10681.  Abstract
  • Liao, HX; Chen, X; Munshaw, S; Zhang, R; Marshall, DJ; Vandergrift, N; Whitesides, JF; Lu, X; Yu, JS; Hwang, KK; Gao, F; Markowitz, M; Heath, SL; Bar, KJ; Goepfert, PA; Montefiori, DC; Shaw, GC; Alam, SM; Margolis, DM; Denny, TN; Boyd, SD; Marshal, E; Egholm, M; Simen, BB; Hanczaruk, B; Fire, AZ; Voss, G; Kelsoe, G; Tomaras, GD; Moody, MA; Kepler, TB; Haynes, BF. Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. Journal of Experimental Medicine. 2011;208:2237-2249.  Abstract
  • Moody, MA; Zhang, R; Walter, EB; Woods, CW; Ginsburg, GS; McClain, MT; Denny, TN; Chen, X; Munshaw, S; Marshall, DJ; Whitesides, JF; Drinker, MS; Amos, JD; Gurley, TC; Eudailey, JA; Foulger, A; DeRosa, KR; Parks, R; Meyerhoff, RR; Yu, JS; Kozink, DM; Barefoot, BE; Ramsburg, EA; Khurana, S; Golding, H; Vandergrift, NA; Alam, SM; Tomaras, GD; Kepler, TB; Kelsoe, G; Liao, HX; Haynes, BF. H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination. PLoS One. 2011;6:e25797.  Abstract
  • Morris, L; Chen, X; Alam, M; Tomaras, G; Zhang, R; Marshall, DJ; Chen, B; Parks, R; Foulger, A; Jaeger, F; Donathan, M; Bilska, M; Gray, ES; Abdool Karim, SS; Kepler, TB; Whitesides, J; Montefiori, D; Moody, MA; Liao, HX; Haynes, BF. Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting. PLoS One. 2011;6:e23532.  Abstract
  • Verkoczy, L; Kelsoe, G; Moody, MA; Haynes, BF. Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies. Current Opinion in Immunology. 2011;23:383-390.  Abstract
  • Warner, DA; Moody, MA; Telemeco, RS. Is water uptake by reptilian eggs regulated by physiological processes of embryos or a passive hydraulic response to developmental environments?. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology. 2011;160:421-425.  Abstract
  • Whittle, JR; Zhang, R; Khurana, S; King, LR; Manischewitz, J; Golding, H; Dormitzer, PR; Haynes, BF; Walter, EB; Moody, MA; Kepler, TB; Liao, HX; Harrison, SC. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proceedings of the National Academy of Sciences of USA. 2011;108:14216-14221.  Abstract
  • Zhu, Z; Qin, HR; Chen, W; Zhao, Q; Shen, X; Schutte, R; Wang, Y; Ofek, G; Streaker, E; Prabakaran, P; Fouda, GG; Liao, HX; Owens, J; Louder, M; Yang, Y; Klaric, KA; Moody, MA; Mascola, JR; Scott, JK; Kwong, PD; Montefiori, D; Haynes, BF; Tomaras, GD; Dimitrov, DS. Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. Journal of Virology. 2011;85:11401-11408.  Abstract
  • Alter, G; Moody, MA. The humoral response to HIV-1: new insights, renewed focus. Journal of Infectious Diseases. 2010;202 Suppl 2:S315-S322.  Abstract
  • Moody, MA; Liao, HX; Alam, SM; Scearce, RM; Plonk, MK; Kozink, DM; Drinker, MS; Zhang, R; Xia, SM; Sutherland, LL; Tomaras, GD; Giles, IP; Kappes, JC; Ochsenbauer-Jambor, C; Edmonds, TG; Soares, M; Barbero, G; Forthal, DN; Landucci, G; Chang, C; King, SW; Kavlie, A; Denny, TN; Hwang, KK; Chen, PP; Thorpe, PE; Montefiori, DC; Haynes, BF. Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. Journal of Experimental Medicine. 2010;207:763-776.  Abstract
  • Robinson, AB; DeWitt, EM; Schanberg, LE; Moody, MA. Necrotizing fasciitis caused by Haemophilus influenzae type E in a 17-year-old girl with systemic lupus erythematosus. Journal of Clinical Rheumatology: practical reports on rheumatic and musculoskeletal disease. 2010;16:49-50.  Abstract
  • Levesque, MC; Moody, MA; Hwang, KK; Marshall, DJ; Whitesides, JF; Amos, JD; Gurley, TC; Allgood, S; Haynes, BB; Vandergrift, NA; Plonk, S; Parker, DC; Cohen, MS; Tomaras, GD; Goepfert, PA; Shaw, GM; Schmitz, JE; Eron, JJ; Shaheen, NJ; Hicks, CB; Liao, HX; Markowitz, M; Kelsoe, G; Margolis, DM; Haynes, BF. Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. PLoS Medicine. 2009;6:e1000107.  Abstract
  • Liao, HX; Levesque, MC; Nagel, A; Dixon, A; Zhang, R; Walter, E; Parks, R; Whitesides, J; Marshall, DJ; Hwang, KK; Yang, Y; Chen, X; Gao, F; Munshaw, S; Kepler, TB; Denny, T; Moody, MA; Haynes, BF. High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. Journal of Virological Methods. 2009;158:171-179.  Abstract
  • Moody, MA; Haynes, BF. Antigen-specific B cell detection reagents: use and quality control. Cytometry Part A. 2008;73:1086-1092.  Abstract
  • Roederer, M; Moody, MA. Polychromatic plots: graphical display of multidimensional data. Cytometry Part A. 2008;73:868-874.  Abstract
  • Haynes, BF; Moody, MA; Verkoczy, L; Kelsoe, G; Alam, SM. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Human Antibodies. 2005;14:59-67.  Abstract