Publications - 2010


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  1. Kepler TB, Sample C, Hudak K, Roach J, Haines A, Walsh A, Ramsburg EA. Chiropteran types I and II interferon genes inferred from genome sequencing traces by a statistical gene-family assembler. BMC Genomics. 2010 Jul 21. 11:444.
  2. Suh HS, Cosenza-Nashat M, Choi N, Zhao ML, Li JF, Pollard JW, Jirtle RL, Goldstein H, Lee SC. Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders. Am J Pathol. 2010 Nov. 177(5): 2446-58.
  3. Kramer HB, Lavender KJ, Qin L, Stacey AR, Liu MK, di Gleria K, Simmons A, Gasper-Smith N, Haynes BF, McMichael AJ, Borrow P, Kessler BM. Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection. PLoS Pathog. 2010 May 6. 6(5): e1000893.
  4. Yu JS, Ma B, Scearce RM, Liao HX, Haynes BF. Anti-Ebola MAb17A3 Reacts with Bovine and Human Alpha-2-macroglobulin Proteins. J Virol Methods. 2010 Sep. 168(1-2): 248-50.
  5. Liu C, Chen BJ, Deoliveira D, Sempowski GD, Chao NJ, Storms RW. Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation. Blood. 2010 Dec 16. 116(25): 5518-27.
  6. Ahn S-H, Deshmukh H, Johnson N, Cowell LG, Rude TH, Scott, Charlotte L. Nelson, Aimee K. Zaas, Douglas A. Marchuk, Sehoon Keum, Supaporn Lamlertthon, Batu K. Sharma-Kuinkel, Gregory D. Sempowski, Vance G. Fowler, Jr. 2010 Two Genes on A/J Chromosome 18 Are Associated with Susceptibility to Staphylococcus aureus Infection by Combined Microarray and QTL Analyses. PLoS Pathog. 6(9): e1001088.
  7. Chen BJ, Deoliveira D, Spasojevic I, Sempowski GD, Jiang C, Owzar K, Wang X, Gesty-Palmer D, Cline JM, Bourland JD, Dugan G, Meadows SK, Daher P, Muramoto G, Chute JP, Chao NJ. Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One. 2010 Jun 16. 5(6):e11056.
  8. Davis CC, Marti LC, Sempowski GD, Jeyaraj DA, Szabolcs P. Interleukin-7 permits Th1/Tc1 maturation and promotes ex vivo expansion of cord blood T cells: a critical step toward adoptive immunotherapy after cord blood transplantation. Cancer Res. 2010 Jul 1;70(13):5249-58.
  9. Na I,Lu SX, Yim N, Goldberg GL, Tsai J, Rao U, Smith OM, King CG, Suh D, Hirschhorn-Cymerman D, Palomba L, Penack O, Holland AM, Jenq RR, Ghosh A, Tran H, Merghoub T, Liu C, Sempowski GD, Ventevogel MS, Beauchemin N, Furie B, Furie B, and van den Brink MRM. The Cytolytic Molecules Fas ligand and TRAIL are required for thymic Graft-versus-Host-Disease. J Clin Invest. 2010 Jan 4. 120(1): 343-56.
  10. Alderman TS, Frothingham R, and Sempowski GD. 2010. Validation of an Animal Isolation Imaging Chamber for Use in Animal Biosafety Level-3 Containment. Applied Biosafety. 15:62-66.
  11. Davis CC, Marti LC, Sempowski GD, and Szabolocs P. 2010. IL-7 Permits Th1/Tc1 Maturation And Promotes Ex-Vivo Expansion of Cord Blood T Cells: A Critical Step Toward Adoptive Immunotherapy After Cord Blood Transplantation. Cancer Res. 2010 Jul 1. 70(13): 5249-58.
  12. Chen BJ, Deoliveira D, Spasojevic I, Sempowski GD, Jiang C, Owzar K, Wang X, Gesty-Palmer D, Cline JM, Bourland JD, Dugan G, Meadows SK, Daher P, Muramoto G, Chute JP, and Chao NJ. 2010. Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One. 2010 Jun 16. 5(6): e11056.
  13. Ahn S, Deshmukh H, Johnson N, Cowell LG, Rude TH, Scott WK, Nelson CL, Zaas AK, Marchuk DA, Keum S, Lamlertthon S, Sharma-Kuinkel BK, Sempowski GD, and Fowler, VG. 2010. Two Genes on A/J Chromosome 18 are Associated with Susceptibility to Staphylococcus aureus Infection by Combined Microarray and Quantitative Trait Locus (QTL) Analyses. PLoS Pathogens. 2010 Sep 2. 6(9): e1001088.
  14. Hultin LE, Chow M, Jamieson BD, O'Gorman MR, Menendez FA, Borowski L, Denny TN, Margolick JB. Comparison of interlaboratory variation in absolute T-cell counts by single-platform and optimized dual-platform methods. Cytometry B Clin Cytom. 2010 May. 78(3):194-200.
  15. McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF. The immune response during acute HIV-1 infection: clues for vaccine development. Nat. Rev. Immunol. 2010 Jan. 10(1): 11-23. PMCID: PMC Journal – In Process
  16. Li H, Bar KJ, Wang S, Decker JM, Chen Y, Sun C, Salazar-Gonzalez JF, Salazar MG, Learn GH, Morgan CJ, Schumacher JE, Hraber P, Giorgi EE, Bhattacharya T, Korber BT, Perelson AS, Eron JJ, Cohen MS, Hicks CB, Haynes BF, Markowitz M, Keele BF, Hahn BH, Shaw GM. High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men. PLoS Pathog. 2010 May 13. 6(5): e1000890.
  17. Lim SY, Chan T, Gelman R, Whitney JB, O’Brien K, Barouch D, Goldstein DB, Haynes BF, and Letvin NL. 2010 Contributions of Mamu-A*01 status and TRIM5 allele expression but not CCL3L copy number variation to the control of SIVmac replication in Indian-origin rhesus monkeys. PLoS Genet. 2010 Jun 24. 6(6): e1000997.
  18. Freel SA, Lamoreaux L, Chattopadhyay PK, Saunders K, Zarkowsky D, Overman RG, Ochsenbauer C, Edmonds TG, Kappes JC, Cunningham CK, Denny TN, Weinhold KJ, Ferrari G, Haynes BF, Koup RA, Graham BS, Roederer M, Tomaras GD. Phenotypic and Functional Profile of HIV-inhibitory CD8 T cells Elicited by Natural Infection and Heterologous Prime/boost Vaccination. J. Virol. 2010 May. 84(10): 4998-5006. PMCID: PMC2863846
  19. Tomaras GD, Haynes BF. Strategies for eliciting HIV-1 inhibitory antibodies. Curr. Opin. HIV AIDS. 2010 Sep. 5(5): 421-7. Review. PMCID: PMC Journal – In Process
  20. Haynes BF, Liao HX, Tomaras GD. Is developing an HIV-1 vaccine possible? Curr. Opin. HIV AIDS. 2010 Sep. 5(5): 362-7. Review.
  21. Bar KJ, Li H, Chamberland A, Tremblay C, Routy JP, Grayson T, Sun C, Wang S, Learn GH, Morgan CJ, Schumacher JE, Haynes BF, Keele BF, Hahn BH, Shaw GM. Wide variation in the multiplicity of HIV-1 infection among injection drug users. J. Virol. 2010 Jun. 84(12): 6241-7.
  22. Liu J, Keele BF, Li H, Keating S, Norris PJ, Carville A, Mansfield KG, Tomaras GD, Haynes BF, Kolodkin-Gal D, Letvin NL, Hahn BH, Shaw GM, Barouch DH. Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys. J. Virol. 2010 Jul. 84(14): 7300-11. PMCID: PMC2937794
  23. Fischer W, Ganusov VV, Giorgi EE, Hraber PT, Keele BF, Leitner T, Han CS, Gleasner CD, Green L, Lo CC, Nag A, Wallstrom TC, Wang S, McMichael AJ, Haynes BF, Hahn BH, Perelson AS, Borrow P, Shaw GM, Bhattacharya T, Korber BT. Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing. PLoS One. 2010 Aug 20. 5(8): e12303.
  24. Gnanakaran S, Daniels MG, Bhattacharya T, Lapedes AS, Sethi A, Li M, Tang H, Greene K, Gao H, Haynes BF, Cohen MS, Shaw GM, Seaman MS, Kumar A, Gao F, Montefiori DC, Korber B. Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies. PLoS Comput. Biol. 2010 Oct 7. 6(10): e1000955. PMCID: PMC2951345
  25. Curtis MG, Walker B, Denny TN. Flow cytometric methods for prenatal and neonatal diagnosis. J Immunol Methods. 2010 Oct 12.
  26. Chen W, Zhu Z, Liao H, Quinnan GV, Jr., Broder CC, Haynes BF, Dimitrov DS. Cross-Reactive Human IgM-Derived Monoclonal Antibodies that Bind to HIV-1 Envelope Glycoproteins. Viruses. 2010 (2): 547-565. NIHMSID #279172
  27. Yoon W, Ma BJ, Fellay J, Huang W, Xia SM, Zhang R, Shianna KV, Liao HX, Haynes BF, Goldstein DB. A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro. AIDS. 2010 Jan 2. 24(1): 155-7. PMCID: PMC Journal – In Process
  28. Geonnotti AR, Bilska M, Yuan X, Ochsenbauer C, Edmonds TG, Kappes JC, Liao HX, Haynes BF, Montefiori DC. Differential inhibition of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and TZM-bl cells by endotoxin-mediated chemokine and gamma interferon production. AIDS Res. Hum. Retroviruses. 2010 (3): 279-91.
  29. Alter G, Moody MA. The humoral response to HIV-1: new insights, renewed focus. J. Infect. Dis. 2010 Oct 15. 202 Suppl 2: S315-22. Review. PMCID: PMC Journal – In Process
  30. McElrath MJ, Haynes BF. Induction of immunity to human immunodeficiency virus type-1 by vaccination. Immunity. 2010 Oct 29. 33(4): 542-54.
  31. Haynes BF, Moody MA, Liao HX, Verkoczy L, Tomaras GD. B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends Mol. Med. 2010 Nov 25. [Epub ahead of print] PMCID: PMC3053087
  32. Nicely NI, Dennison SM, Spicer L, Scearce RM, Kelsoe G, Ueda Y, Chen H, Liao HX, Alam SM, Haynes BF. Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region. Nat. Struct. Mol. Biol. 2010 Dec. 17(12): 1492-4.
  33. Santra S, Liao HX, Zhang R, Muldoon M, Watson S, Fischer W, Theiler J, Szinger J, Balachandran H, Buzby A, Quinn D, Parks RJ, Tsao CY, Carville A, Mansfield KG, Pavlakis GN, Felber BK, Haynes BF, Korber BT, Letvin NL. Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. Nature Medicine. 16(3): 324-8, 2010. PMCID: PMC Journal – In Process
  34. Cella M, Presti R, Vermi W, Lavender K, Turnbull E, Ochsenbauer-Jambor C, Kappes JC, Ferrari G, Kessels L, Williams I, McMichael AJ, Haynes BF, Borrow P, Colonna M; CHAVI Clinical Core B; the NIAID Center for HIV/AIDS Vaccine Immunology. Loss of DNAM-1 contributes to CD8(+) T cell exhaustion in chronic HIV-1 infection. Eur. J. Immunol. 2010 Mar 3.
  35. Pelak K, Shianna KV, Ge D, Maia JM, Zhu M, Smith JP, Cirulli ET, Fellay J, Dickson SP, Gumbs CE, Heinzen EL, Need AC, Ruzzo EK, Singh A, Campbell CR, Hong LK, Lornsen KA, McKenzie AM, Sobreira NL, Hoover-Fong JE, Milner JD, Ottman R, Haynes BF, Goedert JJ, Goldstein DB. The characterization of twenty sequenced human genomes. PLoS Genet. 2010 Sep 9. 6(9): e1001111.
  36. Shen X, Dennison SM, Liu P, Gao F, Jaeger F, Montefiori DC, Verkoczy L, Haynes BF, Alam SM, Tomaras GD. Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution. Proc. Natl. Acad. Sci. U S A. 2010 Mar 30. 107(13): 5972-7.
  37. Zhang MY, Borges AR, Ptak RG, Wang Y, Dimitrov AS, Alam SM, Wieczorek L, Bouma P, Fouts T, Jiang S, Polonis VR, Haynes BF, Quinnan GV, Montefiori DC, Dimitrov DS. Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1. MAbs. 2010 May. 2(3): 266-74. PMCID: PMC2881253
  38. Moody MA, Liao HX, Alam SM, Scearce RM, Plonk MK, Kozink DM, Drinker MS, Zhang R, Xia SM, Sutherland LL, Tomaras GD, Giles IP, Kappes JC, Ochsenbauer-Jambor C, Edmonds TG, Soares M, Barbero G, Forthal DN, Landucci G, Chang C, King SW, Kavlie A, Denny TN, Hwang KK, Chen PP, Thorpe PE, Montefiori DC, Haynes BF. Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. J. Exp. Med. 2010 Apr 12. 207(4): 763-76. PMCID: PMC2856026
  39. Nandi A, Lavine CL, Wang P, Lipchina I, Goepfert PA, Shaw GM, Tomaras GD, Montefiori DC, Haynes BF, Easterbrook P, Robinson JE, Sodroski JG, Yang X; NIAID Center for HIV/AIDS Vaccine Immunology. Epitopes for broad and potent neutralizing antibody responses during chronic infection with human immunodeficiency virus type 1. Virology. 2010 Jan 20. 396(2): 339-48. PMCID: PMC2789835
  40. Haynes BF, Nicely NI, Alam SM. HIV-1 autoreactive antibodies: are they good or bad for HIV-1 prevention? Nat Struct Mol Biol. 2010 May. 17(5): 543-5. No abstract available.
  41. Holl TM, Haynes BF, Kelsoe G. Stromal cell independent B cell development in vitro: Generation and recovery of autoreactive clones. J Immunol Methods. 2010 Mar 31. 354(1-2): 53-67.
  42. Lanasa MC, Allgood SD, Volkheimer AD, Gockerman JP, Whitesides JF, Goodman BK, Moore JO, Weinberg JB, Levesque MC. Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis. Leukemia. 2010 Jan. 24(1): 133-40.
  43. Saunders KO, Freel SA, Overman RG, Cunningham CK, Tomaras GD. Epigenetic regulation of CD8(+) T-lymphocyte mediated suppression of HIV-1 replication. Virology. 2010 Sep 15. 405(1): 234-42.
  44. Y. Lam, Abu-Lail, N.I., Alam, S.M., Zauscher, S. Using microcantilever defelction to detect HIV-1 envelope glycoprotein gp120. Nanomedicine: Nanotechnology, Biology and Medicine. [in press]. 
  45. Lee, S.M., Wyse, A., Lesher, A., Everett, M.L., Lou, L., Holzknecht, Z.E., Whitesides, J.F., Spears, P.A., Bowles, D.E., Lin, S.S., Tonkonogy, S.L. Orndorff, P. E., Bollinger, R. R., and Parker W. Adaptation in a Mouse Colony Monoassociated with Escherichia coli K-12 for More than 1,000 Days. Appl Environ Microbiol. 2010 Jul;76(14):4655-63.
  46. Peiperl L, Morgan C, Moodie Z, Li H, Russell N, Graham BS, Tomaras GD, McElrath MJ, and the NIAID HIV Vaccine Trials Network. Safety and immunogenicity of a replication-defective adenovirus type 5 HIV vaccine in Ad5-seronegative persons: A randomized clinical trial (HVTN study 054). (2010) PloS ONE, 5(10):e13579.
  47. Graham, B.S., McElrath, M.J., Keefer, M.C., Rybczyk, K., Berger, D., Weinhold, K.J., Ottinger, J., Ferarri, G., Montefiori, D.C., Stablein, D., Smith, C., Ginsberg, R., Eldridge, J., Duerr, A., Fast, P., Haynes, B.F.; AIDS Vaccine Evaluation Group. Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity. PLoS One. 5:1-8, 2010.
  48. Specht, A., Telenti, A., Martinez, R., Fellay, J., Bailes, E., Eans, D.T., Carrington, M., Hahn, B.H., Goldstein, D.B., Kirchhof, F. Counteraction of HLA-C-mediated immune control of HIV-1 by Nef. , J. Virol, 84:7300-7311, 2010.